{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T06:37:42Z","timestamp":1721803062514},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,4,26]],"date-time":"2016-04-26T00:00:00Z","timestamp":1461628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Myeloid\u2010related protein 8\/14 (MRP8\/14) forms stable heterodimers and is the major calcium\u2010binding protein secreted by activated granulocytes and monocytes. We evaluated whether serum MRP8\/14 level is a useful indicator for a differential diagnosis of glomerulonephritis (GN)\u2010 and minimal change disease (MC)\u2010 related nephrotic syndrome (NS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum MRP8\/14 complex was evaluated in 37 NS patients with MC or GN. These patients were divided into two groups. Group 1 consisted of 13 NS patients with MC, and group 2 consisted of 24 NS patients with GN. Group 2 was further divided into four subgroups: IgA nephropathy (IgAN; n = 5), Henoch\u2013Sch\u00f6nlein purpura nephritis (HSPN; n = 6), focal segmental glomerulosclerosis (FSGS; n = 12), and acute GN Poststreptococcal acute glomeruloNephritis (PSAGN; n = 1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The clinical manifestations, laboratory findings, serum MRP8\/14 level, and renal accumulation of MRP8 were investigated for each group. No significant inter\u2010group differences were observed for serum total protein, serum albumin, or blood urea nitrogen and urinary protein excretions. Mean serum MRP8\/14 in the IgAN, HSPN, FSGS, and PSAGN groups was higher than in group 1. Further, the mean glomerular and interstitial MRP8 staining scores in the IgAN, HSPN, and PSAGN groups were higher than in group 1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum MRP8\/14 level may be a useful indicator for differential diagnosis between GN\u2010 and MC\u2010 related NS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12947","type":"journal-article","created":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T17:45:20Z","timestamp":1455817520000},"page":"998-1002","source":"Crossref","is-referenced-by-count":2,"title":["Serum myeloid\u2010related protein 8\/14 in minimal change\u2010 and glomerulonephritis\u2010related nephrotic syndrome"],"prefix":"10.1111","volume":"58","author":[{"given":"Shinichiro","family":"Ohara","sequence":"first","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine  Fukushima City Fukushima 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