{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:45:36Z","timestamp":1790628336088,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T00:00:00Z","timestamp":1467072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The use of lactobacillus probiotics has been proposed as an alternative to prophylactic antibiotics for preventing urinary tract infection (UTI) in the era of antibiotic resistance. In this study, the antimicrobial activity of lactobacillus strains against uropathogens, was evaluated and compared with that of antibiotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To evaluate inhibitory activities of lactobacilli against uropathogens, six lactobacillus strains (<jats:italic>L. gasseri<\/jats:italic>, <jats:italic>L. rhamnosus<\/jats:italic>, <jats:italic>L. acidophilus<\/jats:italic>, <jats:italic>L. plantarum<\/jats:italic>, <jats:italic>L. paracasei<\/jats:italic>, <jats:italic>L. acidophilus<\/jats:italic>) and four representative uropathogens of infantile UTI (extended\u2010spectrum beta\u2010lactamase [ESBL](\u2212) <jats:styled-content style=\"fixed-case\"><jats:italic>Escherichia coli<\/jats:italic><\/jats:styled-content>, ESBL(+) <jats:styled-content style=\"fixed-case\"><jats:italic>E. coli<\/jats:italic><\/jats:styled-content>, <jats:italic>Proteus vulgaris<\/jats:italic>, <jats:italic>Enterococcus fecalis<\/jats:italic>) were selected. Lactobacillus strain <jats:italic>in vitro<\/jats:italic> inhibition of each uropathogen was evaluated on MRS agar well diffusion assay and compared with that of commercial antibiotic discs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Average inhibitory zone for each of the six lactobacillus strains against the four uropathogens showed slightly different but consistent inhibition (inhibitory zone diameter, 10.5\u201320.0 mm). This was different to that of the antibiotic discs, which had a wider range of inhibition (inhibitory zone diameter, &lt;6.0\u201327.5 mm) depending on the uropathogen resistance pattern. The inhibitory zone of the six lactobacillus strains was between that of sensitive and resistant antibiotics (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lactobacillus strains had similar moderate antimicrobial activities against uropathogens. Further research is needed to ascertain the strains with the best probiotic potential.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.12949","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T11:00:30Z","timestamp":1455188430000},"page":"1009-1013","source":"Crossref","is-referenced-by-count":48,"title":["Antimicrobial activity of lactobacillus strains against uropathogens"],"prefix":"10.1111","volume":"58","author":[{"given":"Yoon Hee","family":"Shim","sequence":"first","affiliation":[{"name":"Department of Pediatrics Ewha Women's University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Joo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ewha Women's University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ewha Women's University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.88.5.444"},{"key":"e_1_2_6_3_1","first-page":"137","article-title":"Comparison of genomic profiles of \n                     Escherichia coli\n                   isolates from urinary tract infections","volume":"62","author":"Usein CR","year":"2003","journal-title":"Roum. Arch. Microbiol. Immunol."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-005-0043-1"},{"key":"e_1_2_6_5_1","first-page":"973","article-title":"Recurrent urethritis in women","volume":"108","author":"Bruce AW","year":"1973","journal-title":"Can. Med. Assoc. J."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.11.6.654-659.1980"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/515635"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0974-z"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00323-08"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2006.02981.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2007.11.003"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2008.02.001"},{"key":"e_1_2_6_13_1","first-page":"260","article-title":"In vitro anti\u2010bacterial and anti\u2010adherence effects of Lactobacillus delbrueckii subsp bulgaricus on \n                     Escherichia coli","volume":"8","author":"Abedi D","year":"2013","journal-title":"Res. Pharm. Sci."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i20.2472"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2007.08.003"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2011.07.010"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2009.21.3.243"},{"key":"e_1_2_6_18_1","first-page":"6607","article-title":"Lactobacillus for preventing recurrent urinary tract infections in women: Metaanalysis","volume":"20","author":"Grin PM","year":"2013","journal-title":"Can. J. Urol."},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/523341"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-009-0492-9"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2013.0030"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmp001"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31815a5780"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.6.1751-1760.2001"},{"key":"e_1_2_6_25_1","first-page":"32","article-title":"Instillation of lactobacillus and stimulation of indigenous organisms to prevent recurrence of urinary tract infections","volume":"23","author":"Reid G","year":"1995","journal-title":"Microecol. Ther."},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992280404300113"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7302.1571"},{"key":"e_1_2_6_28_1","first-page":"13","article-title":"Lactobacillus byproducts inhibit the growth and virulence of uropathogenic Escherichia coli","volume":"60","author":"Cadieux PA","year":"2009","journal-title":"J. Physiol. Pharmacol."},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.49.2.320-324.1985"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-011-0006-2"},{"key":"e_1_2_6_31_1","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1128\/aem.62.6.1958-1963.1996","article-title":"Inhibition of initial adhesion of uropathogenic Enterococcus faecalis by biosurfactant from lactobacillus isolates","volume":"62","author":"Velraeds MC","year":"1996","journal-title":"Appl. Environ. Microbiol."},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-765X.2006.01934.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1605(02)00153-8"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.2000.00887.x"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12949","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.12949","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.12949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T12:51:13Z","timestamp":1694695873000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.12949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,28]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/ped.12949"],"URL":"https:\/\/doi.org\/10.1111\/ped.12949","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,28]]}}}