{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:39:55Z","timestamp":1758634795689},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T00:00:00Z","timestamp":1465344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although the effectiveness of subarachnoid continuous drug infusion has been established in cancer pain management, its clinical use in children is rare. A 14\u2010year\u2010old girl with neurofibromatosis type I complained of right leg pain stemming from a growing tumor on her right buttock. Continuous and breakthrough right leg pain were unbearable, even at high doses of systemic opioids that caused severe constipation and deep sedation. Subsequent continuous infusion of bupivacaine and morphine through a subarachnoid catheter effectively relieved the girl's pain. The corresponding decrease in systemic opioid also improved her activities of daily living. The patient eventually died of cachexia due to the rapidly growing buttock lesion that was pathologically confirmed post\u2010mortem as a malignant peripheral nerve sheath tumor. Subarachnoid continuous drug infusion may be very useful in controlling severe pain with few side\u2010effects, even in the field of pediatric palliative care.<\/jats:p>","DOI":"10.1111\/ped.12952","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T07:04:50Z","timestamp":1465369490000},"page":"760-763","source":"Crossref","is-referenced-by-count":7,"title":["Effectiveness of subarachnoid drug infusion for pediatric tumor\u2010related pain"],"prefix":"10.1111","volume":"58","author":[{"given":"Tsukasa","family":"Higuchi","sequence":"first","affiliation":[{"name":"Department of General Pediatrics Nagano Children's Hospital  Azumino Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics Nagano Children's Hospital  Azumino Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics Nagano Children's Hospital  Azumino Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kisei","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics Nagano Children's Hospital  Azumino Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouichi","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics Nagano Children's Hospital  Azumino Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiyuki","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Resuscitology Shinshu University School of Medicine  Matsumoto Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,8]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"WHO Guidelines on the Pharmacological Treatment of Persisting Pain in Children with Medical Illnesses","author":"World Health Organization","year":"2013"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.02.118"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2512\/jspm.4.317"},{"key":"e_1_2_5_5_1","first-page":"491","article-title":"Two cases of refractory cancer pain successfully treated with intrathecal injection of high\u2010dose bupivacaine","volume":"20","author":"Kudo N","year":"2013","journal-title":"JJSPC"},{"key":"e_1_2_5_6_1","first-page":"3151","article-title":"Exploration of cancer pain treatment by morphine infusion through an embedded device","volume":"12","author":"Yang Y","year":"2011","journal-title":"Asian Pac. 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