{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:42:18Z","timestamp":1785782538500,"version":"3.56.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,7,24]],"date-time":"2016-07-24T00:00:00Z","timestamp":1469318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There have been no previous studies regarding whether combined use of Polymyxin B\u2010immobilized fiber column direct hemoperfusion (PMX\u2010DHP) and continuous hemodiafiltration (CHDF) is helpful in the treatment of preterm infants with systemic inflammatory response syndrome (SIRS) and hypercytokinemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review was carried out of 18 SIRS infants born at gestational week 24\u201328. Eight with blood interleukin (IL)\u20106 \u2265 1000 pg\/mL were treated actively with 2 h PMX\u2010DHP followed by 2 h PMX\u2010DHP and CHDF. Ten with IL\u20106 &lt; 500 pg\/mL were treated conventionally (with neither PMX\u2010DHP nor CHDF) and served as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Demographic characteristics were similar except for IL\u20106, arterial\u2010to\u2010alveolar oxygen tension ratio (a\/APO<jats:sub>2<\/jats:sub>), and number of immature neutrophils between the two groups. Baseline a\/APO<jats:sub>2<\/jats:sub> was significantly lower in infants with than without active treatment (0.44 vs 0.67, respectively, <jats:italic>P<\/jats:italic> = 0.002). After 4 h treatment, the IL\u20106 decreased to &lt; 500 pg\/mL in all eight infants, and a\/APO<jats:sub>2<\/jats:sub> improved significantly to 0.62 (<jats:italic>P<\/jats:italic> = 0.006). Bronchopulmonary dysplasia occurred in a similar proportion (63%, 5\/8 vs 80%, 8\/10, respectively), but the number of days on inhaled oxygen (30 vs 47 days, respectively, <jats:italic>P<\/jats:italic> = 0.033) and tracheal intubation (36 vs 51 days, respectively, <jats:italic>P<\/jats:italic> = 0.040) was significantly lower in infants with than without active treatment. Prevalence of adverse events was similar (13%, 1\/8 vs 50%, 5\/10 for active vs conventional treatment, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Active treatment with PMX\u2010DHP and CHDF was helpful in the reduction of days on inhaled oxygen and tracheal intubation in preterm SIRS infants with hypercytokinemia. Further prospective randomized studies are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13006","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T18:49:12Z","timestamp":1460314152000},"page":"1176-1182","source":"Crossref","is-referenced-by-count":10,"title":["Polymyxin B\u2010immobilized fiber column direct hemoperfusion and continuous hemodiafiltration in premature neonates with systemic inflammatory response syndrome"],"prefix":"10.1111","volume":"58","author":[{"given":"Yoshinobu","family":"Maede","sequence":"first","affiliation":[{"name":"Department of Neonatology, Perinatal Medical Center Kagoshima City Hospital  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ibara","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Perinatal Medical Center Kagoshima City Hospital  Kagoshima 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