{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:37:17Z","timestamp":1770511037030,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T00:00:00Z","timestamp":1470787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to compare perinatal, neonatal characteristics and neurodevelopmental prognosis of preterm infants born after <jats:italic>in vitro fertilization<\/jats:italic> (IVF) and spontaneous multiple pregnancy, and to evaluate the factors affecting neurodevelopmental outcome at 24\u201336 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 125 preterm infants, 65 from spontaneous and 60 from IVF multiple pregnancy were evaluated in terms of neurodevelopmental outcome at the age of 24\u201336 months. Mean maternal age, chronic maternal disease, birthweight, gestational week, gender, APGAR score, neonatal intensive care unit admission, presence of congenital anomalies, referral to follow up, rehospitalization and socioeconomic status were investigated. Gross Motor Function Classification System and Denver II Developmental Screening Test were carried out. Local ethics committee approved the study (12.10.2010; no: 305).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean maternal age, chronic maternal illness, pregnancy\u2010related diseases, 5 min APGAR score, rate of cesarean delivery and referral to follow up were significantly higher in the IVF group (<jats:italic>P<\/jats:italic> &lt; 0.05). Neurological examination identified increased muscle tone in two children (1.6%); only one infant in the IVF group had cerebral palsy. A total of 26 subjects (20.8%; spontaneous group, n =17, 26.2%; IVF group, n = 9, 15%) had abnormal Denver II findings, mostly in language (8.8%) and personal\u2013social (8.0%) development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Morbidity, length of hospitalization and neurodevelopmental outcome of preterm infants born after spontaneous and IVF multiple pregnancy are similar. Delays in language and personal\u2013social development were the most common neurodevelopmental abnormalities. Even within similar socioeconomic status, parents in the IVF group were more compliant with follow up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13012","type":"journal-article","created":{"date-parts":[[2016,4,16]],"date-time":"2016-04-16T06:06:46Z","timestamp":1460786806000},"page":"1284-1290","source":"Crossref","is-referenced-by-count":12,"title":["Neurodevelopment of preterm infants born after <i>in vitro<\/i> fertilization and spontaneous multiple pregnancy"],"prefix":"10.1111","volume":"58","author":[{"given":"Mehmet","family":"Ramo\u011flu","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology Ankara University Medical Faculty Ankara Turkey"},{"name":"Department of Pediatrics Bak\u0131rk\u00f6y Maternity and Children's Education Hospital \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sultan","family":"Kavuncuo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Neonatology Bak\u0131rk\u00f6y Maternity and Children's Education Hospital \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esin","family":"Aldemir","sequence":"additional","affiliation":[{"name":"Department of Neonatology Bak\u0131rk\u00f6y Maternity and Children's Education Hospital \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Co\u015fkun","family":"Yarar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Bak\u0131rk\u00f6y Maternity and Children's Education Hospital \u0130stanbul Turkey"},{"name":"Department of Pediatric Neurology Osmangazi University Eski\u015fehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Eras","sequence":"additional","affiliation":[{"name":"Developmental Behavioral Pediatrics Unit Department of Neonatology Zekai Tahir Burak Maternity and Children's Education Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,10]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"698","volume-title":"Nelson Textbook of Pediatrics","author":"Stoll BJ","year":"2007"},{"issue":"6","key":"e_1_2_8_3_1","first-page":"1","article-title":"Infant mortality statistics from the 2007 period linked birth\/infant death data set","volume":"59","author":"Mathews TJ","year":"2011","journal-title":"Natl. 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