{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:47:33Z","timestamp":1761490053630},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T00:00:00Z","timestamp":1468972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Influenza infections often cause pneumonia, but there is limited information on thrombotic microangiopathy (<jats:styled-content style=\"fixed-case\">TMA<\/jats:styled-content>) in these circumstances. We report the case of an 11\u2010year\u2010old boy who developed <jats:styled-content style=\"fixed-case\">TMA<\/jats:styled-content> during the acute phase of H1N1 influenza. Plasma von Willebrand factor (<jats:styled-content style=\"fixed-case\">VWF<\/jats:styled-content>) was elevated, whereas a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (<jats:styled-content style=\"fixed-case\">ADAMTS<\/jats:styled-content>13) activity was mildly reduced in the absence of <jats:styled-content style=\"fixed-case\">ADAMTS<\/jats:styled-content>13\u2010neutralizing autoantibody, resulting in low ratio of <jats:styled-content style=\"fixed-case\">ADAMTS<\/jats:styled-content>13 to <jats:styled-content style=\"fixed-case\">VWF<\/jats:styled-content>. The patient was treated intensively, including plasma exchange, and he recovered from the <jats:styled-content style=\"fixed-case\">TMA<\/jats:styled-content>. He developed pulmonary embolism (<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>), however, after removal of the central venous catheter. The findings suggested that influenza\u2010associated cytokines enhanced the release of unusually large <jats:styled-content style=\"fixed-case\">VWF<\/jats:styled-content> multimers from vascular endothelial cells and promoted the formation of platelet thrombi and <jats:styled-content style=\"fixed-case\">TMA<\/jats:styled-content>. Subsequent analysis further indicated the presence of familial protein S deficiency, and it seemed likely that the <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> was more related to this heterozygous protein S defect.<\/jats:p>","DOI":"10.1111\/ped.13014","type":"journal-article","created":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T06:22:56Z","timestamp":1468995776000},"page":"926-929","source":"Crossref","is-referenced-by-count":10,"title":["Influenza\u2010associated thrombotic microangiopathy with unbalanced von Willebrand factor and a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 levels in a heterozygous protein S\u2010deficient boy"],"prefix":"10.1111","volume":"58","author":[{"given":"Nobuyuki","family":"Tsujii","sequence":"first","affiliation":[{"name":"Department of Pediatrics Nara Medical University Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Nogami","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nara Medical University Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Yoshizawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nara Medical University Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion Medicine Nara Medical University Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayami","family":"Isonishi","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion Medicine Nara Medical University Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion Medicine Nara Medical University Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Midori","family":"Shima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nara Medical University Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp053024"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21143"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0107"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.2706"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1981.00340050131031"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2008.05823.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.4620"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200305392"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110259"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.03.023"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2008.08.020"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1661581"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13014","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.13014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T02:17:31Z","timestamp":1694657851000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.13014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,20]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/ped.13014"],"URL":"https:\/\/doi.org\/10.1111\/ped.13014","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,20]]}}}