{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:19:42Z","timestamp":1782602382533,"version":"3.54.5"},"reference-count":10,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,9,4]],"date-time":"2016-09-04T00:00:00Z","timestamp":1472947200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"T\u00e1rsadalmi Meg\u00fajul\u00e1s Operat\u00edv Program","award":["T\u00c1MOP-4.2.2.A-11\/1\/KONV-2012-0045"],"award-info":[{"award-number":["T\u00c1MOP-4.2.2.A-11\/1\/KONV-2012-0045"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute lymphoid leukemia is the most frequently occurring malignancy in childhood, but acute tubulointerstitial nephritis with associated acute renal failure as the leading manifestation of leukemia is extremely rare. Only a few pediatric cases have been described in the literature. We present a surprising case in which physical examination and initial investigation were not typical for leukemia. Ultrasound showed only modest kidney enlargement while laboratory results indicated acute renal failure. Renal biopsy indicated tubulointerstitial nephritis, and subsequent steroid treatment led to sudden clinical improvement. One month later, however, the patient returned with typical clinical features of leukemia. Re\u2010evaluation of the original kidney biopsy block indicated T\u2010cell acute lymphoid leukemia. The present case highlights the importance of renal biopsy.<\/jats:p>","DOI":"10.1111\/ped.13029","type":"journal-article","created":{"date-parts":[[2016,9,5]],"date-time":"2016-09-05T04:18:29Z","timestamp":1473049109000},"page":"940-942","source":"Crossref","is-referenced-by-count":2,"title":["Acute interstitial nephritis in T\u2010cell leukemia in a pediatric patient"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5315-4298","authenticated-orcid":false,"given":"Erika","family":"Biro","sequence":"first","affiliation":[{"name":"Department of Pediatrics University and Clinical Center of Debrecen Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edit","family":"Szikszay","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University and Clinical Center of Debrecen Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petronella","family":"Peth\u0151\u2010Orosz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University and Clinical Center of Debrecen Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Bigida","sequence":"additional","affiliation":[{"name":"Department of Pathology University and Clinical Center of Debrecen Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgy","family":"Balla","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University and Clinical Center of Debrecen Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University and Clinical Center of Debrecen Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.3.4-5.393"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1915-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4081\/nr.2013.e4","article-title":"Acute interstitial nephritis: etiology, pathogenesis, diagnosis, treatment and prognosis","volume":"5","author":"Sathick IJ","year":"2013","journal-title":"Nephrol. Res. Rev."},{"key":"e_1_2_7_5_1","first-page":"521","article-title":"Acute tubulointerstitial nephritis and acute leukemia: report of 2 cases","volume":"19","author":"Elsurer R","year":"2006","journal-title":"J. Nephrol."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg464"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181fe2e0b"},{"key":"e_1_2_7_8_1","first-page":"416","article-title":"Renal complications in acute leukemias","volume":"83","author":"Munker R","year":"1998","journal-title":"Haematologica"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190310001593148"},{"key":"e_1_2_7_10_1","first-page":"14","article-title":"Acute renal failure and normal blood count: a rare presentation of T\u2010cell acute lymphoblastic leukemia","volume":"3","author":"Asdahl PH","year":"2013","journal-title":"Leuk. Res. 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