{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:08:17Z","timestamp":1786950497386,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,15]],"date-time":"2016-08-15T00:00:00Z","timestamp":1471219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Health and Labour Sciences Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To prevent gastric cancer, a test\u2010and\u2010treat strategy for <jats:italic>Helicobacter pylori<\/jats:italic> has been proposed. This retrospective study assessed the clinical features, efficacy and safety of treatment for <jats:italic>H. pylori<\/jats:italic> infection in children and adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Questionnaires concerning the clinical features and treatment of <jats:italic>H. pylori<\/jats:italic> in children and adolescents were sent to doctors in 2013. It included questions on patient background, <jats:italic>H. pylori\u2010<\/jats:italic>associated disease, first\u2010 and second\u2010line treatment, success or failure of eradication, resistance to antibiotics, and occurrence of adverse events. In 2014, serious adverse events associated with treatment were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Invitation letters and questionnaires were sent to 1097 doctors, of whom 409 (37.3%) participated. Finally, 332 patients (mean age, 11.6 \u00b1 3.4 years; male, n = 200) treated from 1997 to 2013 were analyzed. <jats:italic>H. pylori\u2010<\/jats:italic>associated gastritis, iron deficiency anemia, and duodenal ulcer occurred most frequently. Success rates for first\u2010 and second\u2010line treatments were 73.1% and 79.6%, respectively. Seventy\u2010six <jats:italic>H. pylori<\/jats:italic> strains were analyzed for resistance to amoxicillin (<jats:styled-content style=\"fixed-case\">AMPC<\/jats:styled-content>) and clarithromycin (<jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content>), and 64 were analyzed for resistance to metronidazole (<jats:styled-content style=\"fixed-case\">MNZ<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content> resistance was most frequent, occurring in 43.4% of patients; that of <jats:styled-content style=\"fixed-case\">MNZ<\/jats:styled-content> was 21.9%. Adverse events were observed in 13.8% of cases. In total, 587 cases of <jats:italic>H. pylori<\/jats:italic> infection were analyzed and no serious adverse events were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment for <jats:italic>H. pylori<\/jats:italic> in children and adolescents is safe, but further studies on treatment regimens should be conducted to improve eradication rates and monitor increasing <jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content> resistance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13038","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T20:22:07Z","timestamp":1464207727000},"page":"57-61","source":"Crossref","is-referenced-by-count":51,"title":["Nationwide survey of <i>Helicobacter pylori<\/i> treatment for children and adolescents in Japan"],"prefix":"10.1111","volume":"59","author":[{"given":"Masumi","family":"Okuda","sequence":"first","affiliation":[{"name":"Department of General Medicine and Community Health Science Hyogo College of Medicine Sasayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Public Health Aichi Medical University School of Medicine Nagakute Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiro","family":"Mabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology National Hospital Organization Hakodate Hospital Hakodate Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Osaki","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Kyorin University School of Medicine Mitaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Kyorin University School of Medicine Mitaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kyowakai Medical Corporation Second Kyoritsu Hospital Kawanishi Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mototsugu","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology National Hospital Organization Hakodate Hospital Hakodate Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91816-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.105367"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.5.2246-2250.2005"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00510.x"},{"key":"e_1_2_8_6_1","first-page":"6735","article-title":"Human gastric carcinogenesis: A multistep and multifactorial process \u2013 First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention","volume":"52","author":"Correa P","year":"1992","journal-title":"Cancer Res."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/161.4.626"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198912073212302"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950615)75:12<2789::AID-CNCR2820751202>3.0.CO;2-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198706183162501"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(05)70403-X"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-004-1381-2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199901000-00027"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302084"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12184"},{"key":"e_1_2_8_17_1","volume-title":"Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically","author":"National Committee for Clinical Laboratory Standards","year":"2000"},{"key":"e_1_2_8_18_1","unstructured":"European Committee on Antimicrobial Susceptibility Testing.Clinical Breakpoint Table v. 5.0 valid from 1 January 2015. [Cited February 2016.] Available from URL:http:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/EUCAST_files\/Breakpoint_tables\/v_5.0_Breakpoint_Table_01.pdf"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61159-9"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0897-8"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-004-1398-6"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03236.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182227e90"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2009.02915.x"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13038","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13038","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.13038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T22:30:06Z","timestamp":1694730606000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.13038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,15]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/ped.13038"],"URL":"https:\/\/doi.org\/10.1111\/ped.13038","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,15]]}}}