{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:50:28Z","timestamp":1764251428048},"reference-count":10,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T00:00:00Z","timestamp":1469577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Abstract<\/jats:title>Extrapontine myelinolysis (EPM<\/jats:styled-content>) is an uncommon disorder in children, with few pediatric cases reported to date. We report the first case of an infant with EPM<\/jats:styled-content> without central pontine myelinolysis (CPM<\/jats:styled-content>) presenting with severe hypernatremia. On admission, the infant had impaired consciousness, mild dehydration, and severe hypernatremia (190\u00a0mmol\/L). The following day, the patient developed abnormal involuntary movements. Brain magnetic resonance imaging (MRI<\/jats:styled-content>) confirmed EPM<\/jats:styled-content> without CPM<\/jats:styled-content>. He recovered without sequelae, and clinical examinations were within normal limits approximately 6\u00a0months after discharge. Brain MRI<\/jats:styled-content> at 1\u00a0year after onset showed complete disappearance of the previous EPM<\/jats:styled-content> regions. To the best of our knowledge, this represents the youngest patient with EPM<\/jats:styled-content> without CPM<\/jats:styled-content> presenting with severe hypernatremia. Given that treatment for osmotic demyelination syndrome (ODS<\/jats:styled-content>) is yet to be established, preventing the development of ODS<\/jats:styled-content> is crucial.<\/jats:p>","DOI":"10.1111\/ped.13042","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T12:34:49Z","timestamp":1469622889000},"page":"936-939","source":"Crossref","is-referenced-by-count":15,"title":["Extrapontine myelinolysis associated with severe hypernatremia in infancy"],"prefix":"10.1111","volume":"58","author":[{"given":"Ryoji","family":"Aoki","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Child Health Nihon University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuji","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Nihon University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuno","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Nihon University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Nihon University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Fuchigami","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Nihon University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shori","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Nihon University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198606123142402"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1243173"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.045906"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307389901400704"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1959.02340140020004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.201764"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-014-1021-y"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073812445908"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073813520496"},{"key":"e_1_2_6_11_1","first-page":"913","article-title":"Extrapontine myelinolysis in infancy: Report of a case","volume":"19","author":"Haspolat S","year":"2004","journal-title":"J. Child Neurol."}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13042","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13042","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.13042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T02:17:38Z","timestamp":1694657858000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.13042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,27]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/ped.13042"],"URL":"https:\/\/doi.org\/10.1111\/ped.13042","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,27]]}}}