{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T18:59:24Z","timestamp":1722970764660},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,9,11]],"date-time":"2016-09-11T00:00:00Z","timestamp":1473552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report multi\u2010organ histopathological changes in a patient with protein\u2010losing enteropathy (<jats:styled-content style=\"fixed-case\">PLE<\/jats:styled-content>) over 12 years after Fontan operation. A 14\u2010year\u2010old boy with right isomerism heart and single ventricle had undergone Fontan procedure at 19 months of age, and <jats:styled-content style=\"fixed-case\">PLE<\/jats:styled-content> was diagnosed at 28 months. He had several episodes of intestinal bleeding and pre\u2010renal failure with elevated creatine, and eventually died of pneumonia. The intrapulmonary small arteries showed medial and intimal thickening resembling pulmonary hypertension. No major ulcerative lesions were found in the small or large intestines. Dilated lymph ducts, one of the characteristic features of <jats:styled-content style=\"fixed-case\">PLE<\/jats:styled-content>, were not seen in mucosal and submucosal areas. Liver cirrhosis was obvious despite little increase in liver enzymes. Histological changes in bilateral kidneys were subtle despite repeated episodes of renal failure. Thus, there may be significant discrepancies between clinical manifestations and multi\u2010organ histological changes in failed Fontan patients.<\/jats:p>","DOI":"10.1111\/ped.13054","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T04:23:09Z","timestamp":1473654189000},"page":"1061-1065","source":"Crossref","is-referenced-by-count":7,"title":["Diverse multi\u2010organ histopathologic changes in a failed Fontan patient"],"prefix":"10.1111","volume":"58","author":[{"given":"Masanori","family":"Mizuno","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology National Cerebral and Cardiovascular Center Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Ohuchi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology National Cerebral and Cardiovascular Center Osaka Japan"},{"name":"Department of Adult Congenital Heart Disease National Cerebral and Cardiovascular Center Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taka\u2010aki","family":"Matsuyama","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cerebral and Cardiovascular Center Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology National Cerebral and Cardiovascular Center Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatsue","family":"Ishibashi\u2010Ueda","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cerebral and Cardiovascular Center Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology National Cerebral and Cardiovascular Center Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2008.00200.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.025"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.02.021"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/021849230601400303"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-013-3811-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-012-0402-9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.08.038"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcp170"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.03.049"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2012.00717.x"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13054","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.13054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T12:51:49Z","timestamp":1694695909000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.13054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,11]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/ped.13054"],"URL":"https:\/\/doi.org\/10.1111\/ped.13054","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,11]]}}}