{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T07:04:32Z","timestamp":1760425472453,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T00:00:00Z","timestamp":1473120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF\u20102015R1D1A1A09059577"],"award-info":[{"award-number":["NRF\u20102015R1D1A1A09059577"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Both histologic chorioamnionitis (<jats:styled-content style=\"fixed-case\">HCAM<\/jats:styled-content>) and <jats:italic>Ureaplasma<\/jats:italic> infection are considered important contributors to perinatal lung injury. We tested the hypothesis that coexistence of maternal <jats:styled-content style=\"fixed-case\">HCAM<\/jats:styled-content> and perinatal <jats:italic>Ureaplasma<\/jats:italic> exposure increases the risk of prolonged mechanical ventilation in extremely low\u2010birthweight (<jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content>) infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was carried out of all <jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content> infants born between January 2008 and December 2013 at a single academic center. Placental pathology and gastric fluid <jats:italic>Ureaplasma<\/jats:italic> data were available for all infants. Culture and polymerase chain reaction were used to detect <jats:italic>Ureaplasma<\/jats:italic> in gastric fluid. Prolonged mechanical ventilation was defined as mechanical ventilation that began within 28 days after birth and continued.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 111 <jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content> infants enrolled, 84 survived beyond 36 weeks of postmenstrual age (<jats:styled-content style=\"fixed-case\">PMA<\/jats:styled-content>) and were included in the analysis. Eighteen infants (21.4%) had both <jats:styled-content style=\"fixed-case\">HCAM<\/jats:styled-content> and <jats:italic>Ureaplasma<\/jats:italic> exposure. Seven infants (8.3%) required mechanical ventilation beyond 36 weeks of <jats:styled-content style=\"fixed-case\">PMA<\/jats:styled-content>. Coexistence of <jats:styled-content style=\"fixed-case\">HCAM<\/jats:styled-content> and <jats:italic>Ureaplasma<\/jats:italic> in gastric fluid was significantly associated with prolonged mechanical ventilation after adjustment for gestational age, sex, mode of delivery, and use of macrolide antibiotics (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 8.7; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.1\u201367.2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Coexistence of maternal <jats:styled-content style=\"fixed-case\">HCAM<\/jats:styled-content> and perinatal <jats:italic>Ureaplasma<\/jats:italic> exposure significantly increases the risk of prolonged mechanical ventilation in <jats:styled-content style=\"fixed-case\">ELBW<\/jats:styled-content> infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13072","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T14:33:05Z","timestamp":1466692385000},"page":"34-40","source":"Crossref","is-referenced-by-count":3,"title":["Coexistence of <i>Ureaplasma<\/i> and chorioamnionitis is associated with prolonged mechanical ventilation"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0693-5627","authenticated-orcid":false,"given":"Euiseok","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Pediatrics Asan Medical Center Children's Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Won","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Pediatrics Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Yeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hallym University Kangdong Sacred Heart Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae\u2010Jung","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hallym University Kangnam Sacred Heart Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haeryoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung Un","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han\u2010Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beyong Il","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Pediatrics Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung\u2010Hwan","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University College of Medicine Seoul 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