{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:57:50Z","timestamp":1777694270592,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T00:00:00Z","timestamp":1478736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Extremely low\u2010birthweight infants (<jats:styled-content style=\"fixed-case\">ELBWI<\/jats:styled-content>) are at greater risk of developing hepatoblastoma than are normal\u2010weight infants. Serum \u03b1\u2010fetoprotein (<jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content>) plays an important role as a tumor marker in the diagnosis of hepatoblastoma, therefore the aim of this study was to determine the changes in serum <jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content> concentration after birth in <jats:styled-content style=\"fixed-case\">ELBWI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were obtained for infants born between January 2005 and March 2008 with birthweight &lt;1000\u00a0g who were followed up at Gunma Children's Medical Center with clinical examinations, including monitoring of the development of hepatoblastoma. The relationship between serum <jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content> concentration and age was analyzed up to 730\u00a0days after birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 95 serum <jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content> measurements were obtained from 23 infants 30\u2013730\u00a0days of age, with gestational age 24\u201332\u00a0weeks, and birthweight 498\u2013982\u00a0g. Log<jats:sub>10<\/jats:sub>(<jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content> [ng\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>]) was significantly correlated with log<jats:sub>10<\/jats:sub>(age [days]) (<jats:italic>r\u00a0<\/jats:italic>=\u00a0\u22120.961, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.000, <jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>95), with the following regression formula: log<jats:sub>10<\/jats:sub>(<jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content> [ng\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>])<jats:italic>\u00a0<\/jats:italic>=\u00a011.063 \u2212 3.752 log<jats:sub>10<\/jats:sub>(age [days]) (adjusted <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup><jats:italic>\u00a0<\/jats:italic>=\u00a00.923, <jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>95). The standard error of the estimate, mean log<jats:sub>10<\/jats:sub>(age [days]), and the sum of squares for log<jats:sub>10<\/jats:sub>(age [days]) were 0.363, 2.503, and 10.579, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A correlation was found between serum <jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content> concentration and age in <jats:styled-content style=\"fixed-case\">ELBWI<\/jats:styled-content>, and the 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> of serum <jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content> concentration was determined for <jats:styled-content style=\"fixed-case\">ELBWI<\/jats:styled-content> up to 2\u00a0years after birth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13090","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T08:27:39Z","timestamp":1468312059000},"page":"159-162","source":"Crossref","is-referenced-by-count":5,"title":["Serum \u03b1\u2010fetoprotein concentration in extremely low\u2010birthweight infants"],"prefix":"10.1111","volume":"59","author":[{"given":"Kenichi","family":"Maruyama","sequence":"first","affiliation":[{"name":"Department of Neonatology Gunma Children's Medical Center Shibukawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70239-7"},{"key":"e_1_2_7_3_1","first-page":"3032","article-title":"Increased risk of hepatoblastoma among immature children with a lower birth weight","volume":"58","author":"Tanimura M","year":"1998","journal-title":"Cancer Res."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2006.00908.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e31819436cf"},{"key":"e_1_2_7_6_1","first-page":"57","article-title":"Follow\u2010up examinations for hepatoblastoma in extremely\u2010low\u2010birth\u2010weight infants born in 2003 to 2008","volume":"69","author":"Maruyama K","year":"2016","journal-title":"Jpn J. 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