{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:59:24Z","timestamp":1780361964934,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,20]],"date-time":"2016-11-20T00:00:00Z","timestamp":1479600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81272957\/H1625"],"award-info":[{"award-number":["81272957\/H1625"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["XJJ2013057"],"award-info":[{"award-number":["XJJ2013057"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Doctoral Program of Higher Education","award":["20120201110063"],"award-info":[{"award-number":["20120201110063"]}]},{"name":"Doctoral Program of Higher Education","award":["20130201120054"],"award-info":[{"award-number":["20130201120054"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>More and more infantile hemangiomas (<jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>) are being treated with propranolol, but the effectiveness, dosage, and treatment course are still in dispute. The aim of this observational study was to describe the therapeutic response, tolerance, and safety of low\u2010dose propranolol in 23 children with <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> of the head and neck.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected from the medical charts of patients treated with low\u2010dose propranolol from December 2009 through November 2011. Oral dose was 1\u20131.5 mg\/kg once per day. Blood pressure and heart rate were monitored during the first 24 h of treatment. In the absence of side\u2010effects, treatment was continued at home and the child was re\u2010evaluated every month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients had a good response, even if treated with corticosteroid previously. Color and growth changes within 1 week were noted. Treatment continued for a mean total duration of 6 months until the <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> had totally disappeared or stabilized. There were no severe adverse reactions. Side\u2010effects were limited and mild, including blood pressure decrease, somnolence, and nausea. No relapse was noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low\u2010dose propranolol appears to be effective and safe for <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>, especially for those patients previously treated with corticosteroid and who had no response or severe side\u2010effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13109","type":"journal-article","created":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T03:47:01Z","timestamp":1479700021000},"page":"213-217","source":"Crossref","is-referenced-by-count":10,"title":["Low\u2010dose propranolol for infantile hemangioma of the head and neck: Analysis of 23 consecutive patients"],"prefix":"10.1111","volume":"59","author":[{"given":"Wenhao","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Affiliated Hospital of Qingdao University Qingdao Shandong China"},{"name":"Department of Oral and Maxillofacial Surgery Stomatology Hospital of Xi'an Jiaotong University College of Medicine Xi'an No. 4 Hospital Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Affiliated Hospital of Qingdao University Qingdao Shandong China"},{"name":"Department of Oral and Maxillofacial Surgery Stomatology Hospital of Xi'an Jiaotong University College of Medicine Xi'an No. 4 Hospital Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Affiliated Hospital of Qingdao University Qingdao Shandong China"},{"name":"Department of Oral and Maxillofacial Surgery Stomatology Hospital of Xi'an Jiaotong University College of Medicine Xi'an No. 4 Hospital Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Affiliated Hospital of Qingdao University Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Affiliated Hospital of Qingdao University Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Qiang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Affiliated Hospital of Qingdao University Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Xi'an No. 4 Hospital Xi'an Shaanxi 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