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Potential side\u2010effects regarding growth failure and bone metabolism have been reported but data are still scarce in pediatric <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six chronic\u2010phase <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> children on <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> treatment with a median age of 9.87 years (range, 5.33\u201312.67 years) were enrolled in the study. Growth, bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>), bone parameters, 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)\u2010vitamin D3 (25\u2010<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content>3) and blood tests including parathyroid hormone, insulin\u2010like growth factor\u20101 (<jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20101), <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content> binding protein 3, thyroid function test and sex hormones were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median duration of <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> treatment was 78.5 months. Height velocity was suppressed during the first 30 months of treatment and improved gradually afterwards. Two patients (33.3%) had decreased lumbar spine <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> z\u2010scores (&lt;1.5 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>). Patients with decreased <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> had higher mean <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> exposure time than those with normal <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>. The majority of patients (<jats:italic>n<\/jats:italic> = 5) had low 25\u2010<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content>3 (&lt;30 ng\/mL), but there was no correlation between <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> and 25\u2010<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content>3 status. Other blood tests were normal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study supports and confirms the need for monitoring the side\u2010effects of <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> treatment on growth, bone density and vitamin D status in pediatric <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>. Prolonged <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> treatment was associated with low <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> without disturbing bone parameters. There was high prevalence of vitamin D insufficiency. Therefore, the beneficial effect of vitamin D supplement should be explored with regard to the effects on height velocity and <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> patients with vitamin D insufficiency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13136","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T15:36:38Z","timestamp":1471620998000},"page":"286-292","source":"Crossref","is-referenced-by-count":23,"title":["Adverse effects of imatinib in children with chronic myelogenous leukemia"],"prefix":"10.1111","volume":"59","author":[{"given":"Worawut","family":"Choeyprasert","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\u2010Oncology Faculty of Medicine Chiang Mai University Chiang Mai 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