{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:01:06Z","timestamp":1762272066270},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,13]],"date-time":"2016-11-13T00:00:00Z","timestamp":1478995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A nationwide, multicenter and observational study was retrospectively conducted to evaluate the clinical utility of Cepharanthin (<jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content>) for pediatric patients with chronic immune thrombocytopenia (<jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical and laboratory data for 46 Japanese patients aged &lt;16 years who were diagnosed as having chronic <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> in 14 hospitals during 2001\u20132011, and were treated with <jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content> for &gt;12 months, were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median daily <jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content> dose was 1 mg\/kg (range, 0.12\u20132 mg\/kg). Median platelet count prior to <jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content> was 20.5 \u00d7 10<jats:sup>9<\/jats:sup>\/L (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>, 8.3\u201353.0 \u00d7 10<jats:sup>9<\/jats:sup>\/L), and then significantly increased to 58.5 \u00d7 10<jats:sup>9<\/jats:sup>\/L (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>, 22.8\u2013115.0 \u00d7 10<jats:sup>9<\/jats:sup>\/L) and 69.0 \u00d7 10<jats:sup>9<\/jats:sup>\/L (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>, 23.0\u2013134.0 \u00d7 10<jats:sup>9<\/jats:sup>\/L) at 12 and 24 months of treatment, respectively. No life\u2010threatening bleeds or moderate\u2013severe adverse events were reported. Of 38 patients who received both corticosteroids (<jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content>, 17 patients (45%) were weaned from <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>, and 15 patients (39%) attained the reduced dose of <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>. The duration from the start of <jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content> to the stopping of <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> was a median of 413 days (range, 49\u20131734 days) in patients who were weaned from <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CEP alone or combined with CS was useful for the management of pediatric chronic ITPs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13151","type":"journal-article","created":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T05:37:00Z","timestamp":1473140220000},"page":"303-308","source":"Crossref","is-referenced-by-count":13,"title":["High\u2010dose Cepharanthin for pediatric chronic immune thrombocytopenia in Japan"],"prefix":"10.1111","volume":"59","author":[{"given":"Taro","family":"Yamazaki","sequence":"first","affiliation":[{"name":"Department of Pediatrics Saitama Medical 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