{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:52:29Z","timestamp":1785945149284,"version":"3.56.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T00:00:00Z","timestamp":1482278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There have been few reports on the outcome of extracorporeal membrane oxygenation (<jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content>) in newborn Japanese infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A review was carried out of 61 neonates with <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> between January 1995 and December 2015 at a single center. <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> was used in neonates with oxygenation index &gt;20 after conventional treatment. Background factors, such as etiology, vascular access mode (veno\u2010venous [<jats:styled-content style=\"fixed-case\">VV<\/jats:styled-content>] or veno\u2010arterial [<jats:styled-content style=\"fixed-case\">VA<\/jats:styled-content>]), number of days with <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content>, and early <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> (within 24 h after birth), were analyzed in relation to outcome with respect to survival to hospital discharge (<jats:styled-content style=\"fixed-case\">SHD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Survival to hospital discharge was achieved in 35 infants (57%), while the remaining 26 died during hospital stay. Gestational age at birth was significantly higher and number of days with <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> was significantly lower in <jats:styled-content style=\"fixed-case\">SHD<\/jats:styled-content> infants compared with those with adverse outcome (median, 4.0 vs 5.5 days, respectively; <jats:italic>P<\/jats:italic> = 0.008). The <jats:styled-content style=\"fixed-case\">SHD<\/jats:styled-content> rate was significantly higher for those with <jats:styled-content style=\"fixed-case\">VV<\/jats:styled-content> than <jats:styled-content style=\"fixed-case\">VA<\/jats:styled-content> vascular access mode (78%, 18\/23 vs 45%, 17\/38, respectively; <jats:italic>P<\/jats:italic> = 0.016), and for those with than without early <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> (72%, 28\/39 vs 32%, 7\/22, respectively; <jats:italic>P<\/jats:italic> = 0.003). The <jats:styled-content style=\"fixed-case\">SHD<\/jats:styled-content> rate was relatively high in neonates with meconium aspiration syndrome (86%, 12\/14), persistent pulmonary hypertension associated with hypoxic ischemic encephalopathy (75%, 6\/8), and emphysema (80%, 4\/5). On stepwise logistic regression analysis two independent factors of <jats:styled-content style=\"fixed-case\">SHD<\/jats:styled-content> were identified: early <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 9.63; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.47\u201337.6) and <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> length &lt;8 days (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 8.05; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.94\u201333.5).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neonates with early <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> and those with <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> duration &lt;8 days may benefit from <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> with respect to <jats:styled-content style=\"fixed-case\">SHD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13178","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T15:50:54Z","timestamp":1475855454000},"page":"438-442","source":"Crossref","is-referenced-by-count":9,"title":["Extracorporeal membrane oxygenation in 61 neonates: Single\u2010center experience"],"prefix":"10.1111","volume":"59","author":[{"given":"Eiji","family":"Hirakawa","sequence":"first","affiliation":[{"name":"Department of Neonatology Perinatal Medical Center Kagoshima City Hospital Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ibara","sequence":"additional","affiliation":[{"name":"Department of Neonatology Perinatal Medical Center Kagoshima City Hospital Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Tokuhisa","sequence":"additional","affiliation":[{"name":"Department of Neonatology Perinatal Medical Center Kagoshima City Hospital Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Maede","sequence":"additional","affiliation":[{"name":"Department of Neonatology Perinatal Medical Center Fukuda Hospital Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Department of Neonatology Perinatal Medical Center Kagoshima City Hospital Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Neonatology Perinatal Medical Center Kagoshima City Hospital Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Perinatal Medical Center Kagoshima City Hospital Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Naitou","sequence":"additional","affiliation":[{"name":"Department of Neonatology Perinatal Medical Center Kagoshima City Hospital Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakatsu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Neonatology Perinatal Medical Center Kagoshima City Hospital Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Kibe","sequence":"additional","affiliation":[{"name":"Department of Neonatology Perinatal Medical Center Kagoshima City Hospital Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Neonatology Perinatal Medical Center Kagoshima City Hospital Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Kurimoto","sequence":"additional","affiliation":[{"name":"Department of Neonatology Perinatal Medical Center Kagoshima City Hospital Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Kamitomo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Perinatal Medical Center Kagoshima City Hospital Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutoshi","family":"Cho","sequence":"additional","affiliation":[{"name":"Maternity and Perinatal Care Center Hokkaido University Hospital Sapporo 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