{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:25:18Z","timestamp":1791836718124,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T00:00:00Z","timestamp":1482278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["26040301"],"award-info":[{"award-number":["26040301"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Information on long\u2010term follow up of childhood\u2010onset anorexia nervosa is scarce. This study investigated long\u2010term (&gt;10 years) course, outcome and prognostic factors for hospitalized childhood\u2010onset anorexia nervosa restricting type (<jats:styled-content style=\"fixed-case\">ANR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010one <jats:styled-content style=\"fixed-case\">ANR<\/jats:styled-content> girls admitted to a single regional center participated. Median age at first admission was 13.3 years (range, 8.6\u201315.6 years). The longitudinal clinical course was retrospectively determined for a median follow\u2010up period of 17.1 years (range, 10.4\u201321.1 years). We analyzed physical, psychological, and social variables to predict partial remission (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>) and full remission (<jats:styled-content style=\"fixed-case\">FR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The completion rate of follow up &gt;10 years was high at 97%. At final evaluation (<jats:italic>n<\/jats:italic> = 38), distribution of prognosis was as follows: <jats:styled-content style=\"fixed-case\">FR<\/jats:styled-content>,<jats:italic> n<\/jats:italic> = 27 (71%); <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>,<jats:italic> n<\/jats:italic> = 6 (16%); and non\u2010remission, <jats:italic>n<\/jats:italic> = 5 (13%). The cumulative ratio of <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FR<\/jats:styled-content> increased during the first 5\u20136 years, and gradually reached a plateau at around 10 years. More than 10 years after the onset, one patient eventually achieved <jats:styled-content style=\"fixed-case\">FR<\/jats:styled-content>, and one patient died. Seven patients were rehospitalized and two died due to suicide during the entire follow up. On multivariate analysis, family disorders\/problems rating score was a significant predictor of <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study included hospitalized <jats:styled-content style=\"fixed-case\">ANR<\/jats:styled-content> children aged \u226415 years, the youngest cohort ever reported. Long\u2010term prognosis is generally favorable, but the mortality rate was 5%. Careful long\u2010term follow up &gt;10 years is needed to evaluate outcome of childhood\u2010onset <jats:styled-content style=\"fixed-case\">ANR<\/jats:styled-content>, and family therapy is important in high\u2010risk patients with family disorders\/problems.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13194","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T14:42:43Z","timestamp":1476888163000},"page":"482-489","source":"Crossref","is-referenced-by-count":24,"title":["Long\u2010term follow up of hospitalized pediatric anorexia nervosa restricting type"],"prefix":"10.1111","volume":"59","author":[{"given":"Keiji","family":"Tasaka","sequence":"first","affiliation":[{"name":"Department of Pediatrics Nishi\u2010Kobe Medical Center Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kousaku","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nishi\u2010Kobe Medical Center Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuo","family":"Takamiya","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nishi\u2010Kobe Medical Center Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin\u2010ichi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Nishi\u2010Kobe Medical Center Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nishi\u2010Kobe Medical Center Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nigami","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nishi\u2010Kobe Medical Center Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-014-0446-z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/15374416.2014.971458"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.8.1284"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.054742"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05363-5"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1176\/ajp.2006.163.8.1433","article-title":"Improved survival in adolescent patients with anorexia nervosa: A comparison of two Swedish national cohorts of female inpatients","volume":"163","author":"Lindblad F","year":"2006","journal-title":"Am. 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