{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:52:22Z","timestamp":1761238342801,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health, Labor Sciences Research Grants"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic intestinal pseudo\u2010obstruction (<jats:styled-content style=\"fixed-case\">CIPO<\/jats:styled-content>) is a rare disabling and life\u2010threatening disorder characterized by severe impairment of gastrointestinal peristalsis. While a number of pharmacotherapeutics have been developed, only a few trials have been carried out for improvement of the pathological condition of <jats:styled-content style=\"fixed-case\">CIPO<\/jats:styled-content> patients. This report describes the results of a nationwide survey on the pharmacotherapy used in pediatric <jats:styled-content style=\"fixed-case\">CIPO<\/jats:styled-content> in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 2012, a nationwide survey was conducted to identify the clinical presentation of <jats:styled-content style=\"fixed-case\">CIPO<\/jats:styled-content> in Japan. Information was gathered on pharmacotherapy. Four categories were created for medicines used in pharmacotherapy: \u201cprobiotics\u201d, \u201cJapanese herbal medicines (Kampo medicines)\u201d, \u201claxatives\u201d, and \u201cprokinetics\u201d.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010two responses were collected from 47 facilities. Of the 62 patients who met the diagnostic criteria, 52 were treated with medications, while the remaining 10 were not. Thirty\u2010four patients were given a total of 49 probiotics; 39 were treated with a total of 50 Kampo medicines; 20 were treated with a total of 28 laxatives; and 26 were given a total of 30 prokinetics, 70% of whom were treated specifically with mosapride.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Traditional Japanese medicines such as Kampo medicines and mosapride are often used to treat <jats:styled-content style=\"fixed-case\">CIPO<\/jats:styled-content> in Japan. Two combinations, that is, probiotics and Kampo medicines; and Kampo medicines and prokinetics, were often used for pediatric <jats:styled-content style=\"fixed-case\">CIPO<\/jats:styled-content> in Japan.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13201","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T04:43:53Z","timestamp":1479185033000},"page":"467-472","source":"Crossref","is-referenced-by-count":10,"title":["Pharmacotherapy for pediatric chronic intestinal pseudo\u2010obstruction: Nationwide survey in Japan"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9366-361X","authenticated-orcid":false,"given":"Naoki","family":"Hashizume","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Kurume University School of Medicine Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Kurume University School of Medicine Kurume Japan"},{"name":"Japanese Study Group of Allied Disorders of Hirschsprung's Disease Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Ushijima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kurume University Medical Center Kurume Japan"},{"name":"Japanese Study Group of Allied Disorders of Hirschsprung's Disease Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Seki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Kurume University School of Medicine Kurume Japan"},{"name":"Japanese Study Group of Allied Disorders of Hirschsprung's Disease Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suguru","family":"Fukahori","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Kurume University School of Medicine Kurume Japan"},{"name":"Japanese Study Group of Allied Disorders of Hirschsprung's Disease Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Muto","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Graduate School of Medical and Dental Sciences Kagoshima University Kagoshima Japan"},{"name":"Japanese Study Group of Allied Disorders of Hirschsprung's Disease Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Matsufuji","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery St Luke's International Hospital Tokyo Japan"},{"name":"Japanese Study Group of Allied Disorders of Hirschsprung's Disease Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Graduate School of Medical Sciences Kyushu University Fukuoka Japan"},{"name":"Japanese Study Group of Allied Disorders of Hirschsprung's Disease Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.2953"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.09.025"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2007.00902.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181a15bfe"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198805000-00003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337528"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-011-0115-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199701000-00021"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/462586"},{"key":"e_1_2_8_11_1","first-page":"28","article-title":"Effect of the herbal medicine dai\u2010kenchu\u2010to on gastrointestinal motility in patients with megacystis\u2010microcolon\u2010intestinal hypoperistalsis syndrome (MMIHS) and chronic idiopathic intestinal pseudo\u2010obstruction (CIIP): report of two cases","volume":"34","author":"Hirakawa H","year":"2009","journal-title":"Tokai J. 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