{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T01:09:46Z","timestamp":1724980186716},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T00:00:00Z","timestamp":1488240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human leukocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>)\u2010G is a non\u2010classical major histocompatibility complex class I antigen characterized by limited polymorphism in its coding region, unique tissue expression pattern in physiologic conditions and immunomodulatory properties. Recently, the level of soluble (s)<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010G was found to be higher in atopic asthma and allergic rhinitis, but this remains to be clarified in wheezy infants. The aim of the present study was therefore to investigate <jats:styled-content style=\"fixed-case\">sHLA<\/jats:styled-content>\u2010G in wheezy infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The subjects consisted of infants with persistent wheezing and positive modified asthma predictive index (<jats:styled-content style=\"fixed-case\">mAPI<\/jats:styled-content>;<jats:italic> n<\/jats:italic> = 30; persistent group) and those with transient wheezing and negative <jats:styled-content style=\"fixed-case\">mAPI<\/jats:styled-content> (<jats:italic>n<\/jats:italic> = 17; transient group). <jats:styled-content style=\"fixed-case\">sHLA<\/jats:styled-content>\u2010G was measured in plasma using enzyme\u2010linked immunosorbent assay. Total immunoglobulin E (IgE) and eosinophil count were measured, and skin testing was performed with a battery of 13 antigens with appropriate positive and negative controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">sHLA<\/jats:styled-content>\u2010G was significantly higher in the persistent wheezing (positive <jats:styled-content style=\"fixed-case\">mAPI<\/jats:styled-content>) group compared with the transient wheezing (negative <jats:styled-content style=\"fixed-case\">mAPI<\/jats:styled-content>) group (<jats:italic>P<\/jats:italic> = 0.008). There was no significant difference in peripheral blood eosinophil count and total IgE between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The increased <jats:styled-content style=\"fixed-case\">sHLA<\/jats:styled-content>\u2010G in infants with persistent wheeze suggests that <jats:styled-content style=\"fixed-case\">sHLA<\/jats:styled-content>\u2010G may be able to be used to distinguish persistent from transient wheeze. Further comprehensive studies are needed on this topic.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13207","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T19:49:01Z","timestamp":1479930541000},"page":"530-533","source":"Crossref","is-referenced-by-count":2,"title":["Increased plasma soluble human leukocyte antigen\u2010G in persistent wheezy infants"],"prefix":"10.1111","volume":"59","author":[{"given":"Fulya","family":"Tahan","sequence":"first","affiliation":[{"name":"Department of Pediatric Allergy School of Medicine Erciyes University Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice","family":"Eke Gungor","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy School of Medicine Erciyes University Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himmet Haluk","family":"Akar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy 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