{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:05:22Z","timestamp":1788433522833,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T00:00:00Z","timestamp":1490054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002635","name":"Inha University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002635","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Severe bronchopulmonary dysplasia often leads to prolonged mechanical ventilation lasting several months. Cyanotic episodes frequently occur in these patients, necessitating long\u2010term sedation and\/or intermittent muscle paralysis. Neurally adjusted ventilatory assist (<jats:styled-content style=\"fixed-case\">NAVA<\/jats:styled-content>) might provide precisely the amount of support that these patients need without sedation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the medical records of preterm infants who underwent tracheostomy and required mechanical ventilation for &gt;6 months during a period of 6 years. We compared two groups of patients: those supported with <jats:styled-content style=\"fixed-case\">NAVA<\/jats:styled-content> for \u22652 months versus those supported by pneumatically triggered assist methods. We also evaluated any change after <jats:styled-content style=\"fixed-case\">NAVA<\/jats:styled-content> use in the <jats:styled-content style=\"fixed-case\">NAVA<\/jats:styled-content> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 14 prematurely born patients who received prolonged ventilation, nine were supported with <jats:styled-content style=\"fixed-case\">NAVA<\/jats:styled-content> and five were supported using other ventilator modes. Duration of continuous sedation was significantly shorter and the bolus use of sedatives was also significantly lower in the <jats:styled-content style=\"fixed-case\">NAVA<\/jats:styled-content> group than in the pneumatically triggered assist group. In addition, the <jats:styled-content style=\"fixed-case\">NAVA<\/jats:styled-content> group received a lower dose of dexamethasone than the pneumatically triggered assist group. Compared with before <jats:styled-content style=\"fixed-case\">NAVA<\/jats:styled-content>, the frequency of cyanotic episodes and of the bolus sedatives was significantly decreased after implementation of <jats:styled-content style=\"fixed-case\">NAVA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For infants on prolonged mechanical ventilation, <jats:styled-content style=\"fixed-case\">NAVA<\/jats:styled-content> could reduce cyanotic episodes and the need for sedatives and dexamethasone. <jats:styled-content style=\"fixed-case\">NAVA<\/jats:styled-content> may be superior to pneumatically triggered modes in terms of the minimization of patient\u2013ventilator dyssynchrony while delivering appropriate respiratory support in premature infants with tracheostomy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13233","type":"journal-article","created":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T13:26:44Z","timestamp":1483795604000},"page":"540-544","source":"Crossref","is-referenced-by-count":27,"title":["Neurally adjusted ventilatory assist for infants under prolonged ventilation"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7548-2284","authenticated-orcid":false,"given":"Juyoung","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pediatrics Inha University College of Medicine Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hwa","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Won","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Hoon","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Inha University College of Medicine Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000143722"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aucc.2010.03.003"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950140106"},{"issue":"1","key":"e_1_2_8_5_1","first-page":"CD000456","article-title":"Synchronized mechanical ventilation for respiratory support in newborn infants","author":"Greenough A","year":"2008","journal-title":"Cochrane Database Syst. 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