{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:52:54Z","timestamp":1759009974621},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T00:00:00Z","timestamp":1491868800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,4]]},"abstract":"Abstract<\/jats:title>Hypocellular acute myeloid leukemia (AML<\/jats:styled-content>) mainly occurs in elderly patients, and is extremely rare in childhood. There is still no established treatment for hypocellular AML<\/jats:styled-content>. We report the case of an 11\u2010year\u2010old boy with hypocellular AML<\/jats:styled-content> who was treated successfully with allogenic bone marrow transplantation (allo\u2010BMT<\/jats:styled-content>). He presented with fever, pallor and pancytopenia. Bone marrow aspiration and biopsy confirmed a diagnosis of hypocellular AML<\/jats:styled-content>. Although low\u2010dose cytarabine induced reduction of blasts, it did not lead to complete remission. He subsequently received myeloablative conditioning and allo\u2010BMT<\/jats:styled-content>. Graft\u2010versus\u2010host disease (GVHD<\/jats:styled-content>) prophylaxis included short\u2010course methotrexate and cyclosporine. Neutrophil engraftment (>5\u00a0\u00d7\u00a0108<\/jats:sup>\/L) and platelet recovery (>10\u00a0\u00d7\u00a01010<\/jats:sup>\/L) were achieved on days 13 and 27, respectively. He developed acute GVHD<\/jats:styled-content> of the skin (grade 2), which responded well to treatment with prednisolone. He has remained in complete remission for 5\u00a0years since allo\u2010BMT<\/jats:styled-content>. We consider allo\u2010BMT<\/jats:styled-content> to be feasible for children with hypocellular AML<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ped.13237","type":"journal-article","created":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T01:30:51Z","timestamp":1491960651000},"page":"490-493","source":"Crossref","is-referenced-by-count":1,"title":["Hypocellular acute myeloid leukemia treated with bone marrow transplantation"],"prefix":"10.1111","volume":"59","author":[{"given":"Dai","family":"Keino","sequence":"first","affiliation":[{"name":"Department of Pediatrics St Marianna University School of Medicine Hospital Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensuke","family":"Kondoh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics St Marianna University School of Medicine Hospital Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Ohyama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics St Marianna University School of Medicine Hospital Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuho","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics St Marianna University School of Medicine Hospital Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Pediatrics St Marianna University School of Medicine Hospital Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pathology Japanese Red Cross Nagoya Daiichi Hospital Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akitoshi","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Pediatrics St Marianna University School of Medicine Hospital Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13755"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(95)00136-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(94)90036-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.046672"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02983786"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3182388966"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930101)71:1<264::AID-CNCR2820710140>3.0.CO;2-8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402592"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830390111"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1995.tb00235.x"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13237","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.13237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T19:42:58Z","timestamp":1694720578000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.13237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/ped.13237"],"URL":"https:\/\/doi.org\/10.1111\/ped.13237","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}