{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T06:11:43Z","timestamp":1694758303052},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T00:00:00Z","timestamp":1491868800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We herein describe a case of systemic juvenile idiopathic arthritis (s\u2010<jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>)\u2010associated macrophage activation syndrome (<jats:styled-content style=\"fixed-case\">MAS<\/jats:styled-content>) in which the <jats:sup>18F<\/jats:sup>fluorodeoxyglucose positron emission tomography (<jats:sup>18<\/jats:sup><jats:styled-content style=\"fixed-case\"><jats:sup>F<\/jats:sup>FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>) findings were characteristic. The pattern of greater <jats:sup>18<\/jats:sup><jats:styled-content style=\"fixed-case\"><jats:sup>F<\/jats:sup>FDG<\/jats:styled-content> accumulation into the spleen compared with the liver was more remarkable in this patient compared with s\u2010<jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>. This pattern, however, was also observed in cases of acute leukemia. In the present patient, serum interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201018 was extremely elevated (255\u00a0000\u00a0pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>), whereas in leukemia patients it is mildly elevated (360\u20131480\u00a0pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>). <jats:sup>18<\/jats:sup><jats:styled-content style=\"fixed-case\"><jats:sup>F<\/jats:sup>FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> might be a useful indicator of s\u2010<jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MAS<\/jats:styled-content> in patients with fever of unknown origin. The pattern of <jats:sup>18<\/jats:sup><jats:styled-content style=\"fixed-case\"><jats:sup>F<\/jats:sup>FDG<\/jats:styled-content> accumulation, however, can also be observed in acute leukemia. The combination of <jats:sup>18<\/jats:sup><jats:styled-content style=\"fixed-case\"><jats:sup>F<\/jats:sup>FDG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content> and serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201018 might be useful for the diagnosis of s\u2010<jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> and MAS.<\/jats:p>","DOI":"10.1111\/ped.13238","type":"journal-article","created":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T01:30:51Z","timestamp":1491960651000},"page":"509-511","source":"Crossref","is-referenced-by-count":0,"title":["<scp>FDG<\/scp>\u2010<scp>PET<\/scp> in macrophage activation syndrome associated with systemic juvenile idiopathic arthritis"],"prefix":"10.1111","volume":"59","author":[{"given":"Masaki","family":"Shimizu","sequence":"first","affiliation":[{"name":"Department of Pediatrics School of Medicine Institute of Medical, Pharmaceutical, and Health Sciences Kanazawa University Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Ikawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics School of Medicine Institute of Medical, Pharmaceutical, and Health Sciences Kanazawa University Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao","family":"Mizuta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics School of Medicine Institute of Medical, Pharmaceutical, and Health Sciences Kanazawa University Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiko","family":"Takakura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics School of Medicine Institute of Medical, Pharmaceutical, and Health Sciences Kanazawa University Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsumi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Pediatrics School of Medicine Institute of Medical, Pharmaceutical, and Health Sciences Kanazawa University Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosei","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics School of Medicine Institute of Medical, Pharmaceutical, and Health Sciences Kanazawa University Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Yachie","sequence":"additional","affiliation":[{"name":"Department of Pediatrics School of Medicine Institute of Medical, Pharmaceutical, and Health Sciences Kanazawa University Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2012.3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000381996.69261.71"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/snuc.2000.7439"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2015.1082686"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-2901-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.68"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-014-8561-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq133"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2015.06.005"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2016.05.010"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13238","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.13238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T19:43:08Z","timestamp":1694720588000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.13238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/ped.13238"],"URL":"https:\/\/doi.org\/10.1111\/ped.13238","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}