{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:40:06Z","timestamp":1770968406483,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T00:00:00Z","timestamp":1491955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>We tested whether direct transcutaneous bilirubin (TcB) measurement from an area unexposed to phototherapy is reliable for estimation of total serum bilirubin (TSB<\/jats:styled-content>) in neonates during phototherapy and whether it contributes to reduction in TSB<\/jats:styled-content> blood sampling in phototherapy decision making.<\/jats:p><\/jats:sec>Methods<\/jats:title>This was a retrospective observational study of term neonates who received phototherapy in the mother's room. TSB<\/jats:styled-content> and TcB from the neonate's sternum were measured before and during phototherapy and compared using linear regression analysis and Bland\u2013Altman plot, respectively. Various cut\u2010offs of TcB for estimating TSB<\/jats:styled-content> during phototherapy at >72\u00a0h after birth were analyzed.<\/jats:p><\/jats:sec>Results<\/jats:title>There were moderate correlations between TSB<\/jats:styled-content> and TcB before (r<\/jats:italic>\u00a0=\u00a00.56) and during (r<\/jats:italic>\u00a0=\u00a00.47) phototherapy in 125 neonates. The mean difference (TSB<\/jats:styled-content>\u2013TcB) before and during phototherapy was 1.2\u00a0\u00b1\u00a01.7\u00a0mg\/dL<\/jats:styled-content> and 1.0\u00a0\u00b1\u00a01.7\u00a0mg\/dL<\/jats:styled-content>, respectively. The 95% limits of agreement for the difference before and during phototherapy ranged from \u22122.1 to 4.5 and from \u22122.3 to 4.3\u00a0mg\/dL<\/jats:styled-content>, respectively. For TSB<\/jats:styled-content> \u226418\u00a0mg\/dL<\/jats:styled-content> during phototherapy, a TcB cut\u2010off of 14\u00a0mg\/dL<\/jats:styled-content> had a specificity of 1.0; with this method, 43% of the TSB<\/jats:styled-content> measurements could have been avoided.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Direct measurement of TcB during phototherapy using a bed\u2010type device is a reliable method to estimate TSB<\/jats:styled-content> in term neonates and would contribute to a reduction in blood sampling. It cannot, however, be used as a substitute for TSB<\/jats:styled-content> measurement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13248","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T20:37:32Z","timestamp":1485290252000},"page":"686-690","source":"Crossref","is-referenced-by-count":15,"title":["Transcutaneous bilirubin measurement during phototherapy in term neonates"],"prefix":"10.1111","volume":"59","author":[{"given":"Yoshinori","family":"Katayama","sequence":"first","affiliation":[{"name":"Department of Pediatrics Takatsuki General Hospital Takatsuki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Enomoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Takatsuki General Hospital Takatsuki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Takatsuki General Hospital Takatsuki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Takei","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Takatsuki General Hospital Takatsuki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Ikegami","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Takatsuki General Hospital Takatsuki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Takatsuki General Hospital Takatsuki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Kye","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Aijinkai Rehabilitation Hospital Takatsuki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2011.02.005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330055"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.2.e17"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.6.1628"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.4.599"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.037804"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2003.tb02510.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-1494"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211141"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2003.012"},{"key":"e_1_2_8_12_1","first-page":"91","article-title":"Total and unbound bilirubin determination using an automated peroxidase micromethod","volume":"28","author":"Shimabuku R","year":"1982","journal-title":"Kobe J. 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