{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:00:26Z","timestamp":1784815226226,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T00:00:00Z","timestamp":1492992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005731","name":"Juntendo University","doi-asserted-by":"publisher","award":["E2726"],"award-info":[{"award-number":["E2726"]}],"id":[{"id":"10.13039\/501100005731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Preterm neonates are born while nephrogenesis is ongoing, and are commonly exposed to factors in a hyperoxic environment that can impair renal development. Oxidative stress has also been implicated in the development of retinopathy of prematurity (<jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>). The rat model of oxygen\u2010induced retinopathy (<jats:styled-content style=\"fixed-case\">OIR<\/jats:styled-content>) is the most clinically relevant model of <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> because its biologic features closely resemble those of <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> in preterm infants. We investigated impaired renal development in a rat model of <jats:styled-content style=\"fixed-case\">OIR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Newborn Sprague\u2013Dawley rats were maintained in either a normoxic (room air, 21% O<jats:sub>2<\/jats:sub>; control group) or a controlled hyperoxic (80% O<jats:sub>2<\/jats:sub>; <jats:styled-content style=\"fixed-case\">OIR<\/jats:styled-content> group) environment from birth to postnatal day (P) 12. All pups were then raised in room air from P12 to P19.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The hyperoxic environment led to significantly higher urinary excretion of 8\u2010hydroxy\u20102\u2032\u2010deoxyguanosine, a marker of oxidative <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> damage, and a reduction in nephrogenic zone width at P5 in <jats:styled-content style=\"fixed-case\">OIR<\/jats:styled-content> pups. Additionally, glomerular count was significantly reduced by 20% in the <jats:styled-content style=\"fixed-case\">OIR<\/jats:styled-content> group, and avascular and neovascular changes in the retina were observed only in the <jats:styled-content style=\"fixed-case\">OIR<\/jats:styled-content> group at P19. Messenger <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> levels of vascular endothelial growth factor\u2010A (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\u2010A) and platelet\u2010derived growth factor\u2010\u03b2, essential angiogenic cytokines for glomerulogenesis, in the renal cortex were significantly lower at P5 and significantly higher at P19 in the <jats:styled-content style=\"fixed-case\">OIR<\/jats:styled-content> group compared with controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Renal impairment was caused by exposure to a hyperoxic environment during nephrogenesis, and the pathology of the impaired nephrogenesis in this <jats:styled-content style=\"fixed-case\">OIR<\/jats:styled-content> model reflects the characteristics of <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> observed in preterm infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13264","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T18:02:41Z","timestamp":1487268161000},"page":"704-710","source":"Crossref","is-referenced-by-count":13,"title":["Impaired nephrogenesis in neonatal rats with oxygen\u2010induced retinopathy"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8814-6885","authenticated-orcid":false,"given":"Mayu","family":"Nakagawa","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Graduate School of Medicine Juntendo University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Nishizaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Faculty of Medicine Juntendo University Tokyo 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