{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:52:09Z","timestamp":1787503929464,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T00:00:00Z","timestamp":1498608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Febrile status epilepticus can have neurological sequelae. The type of sequelae, however, depend on the etiology, including infection due to viral agents such as the influenza virus. Respiratory syncytial virus (\n                      <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>\n                      ) infection in childhood may also contribute to this. The aim of this study was therefore to characterize febrile status epilepticus associated with\n                      <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>\n                      infection, and to determine whether this type of infection is a risk factor for neurological sequelae in febrile status epilepticus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We reviewed the medical records of children aged \u22643\u00a0years with febrile status epilepticus who were admitted to a tertiary hospital between January 2007 and December 2011. The differences between the\n                      <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>\n                      \u2010positive and\n                      <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>\n                      \u2010negative groups were evaluated according to the demographic and clinical data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 99 patients with febrile status epilepticus who had been tested for\n                      <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>\n                      infection were identified. Three patients in the\n                      <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>\n                      \u2010positive group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a019) and four in the\n                      <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>\n                      \u2010negative group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a080) presented with bronchiolitis. The incidence of intubation and anti\u2010seizure drug treatment in the\n                      <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>\n                      \u2010positive group was significantly higher than in the \u2010negative group. While all of the patients in the\n                      <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>\n                      \u2010negative group recovered completely, six patients in the\n                      <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>\n                      \u2010positive group developed encephalopathy and profound neurological sequelae. In five of the six patients, diffusion\u2010weighted magnetic resonance imaging showed subcortical white matter lesions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>\n                      infection in the absence of bronchiolitis can initially present as febrile status epilepticus and subsequently develop into acute encephalopathy with profound neurological sequelae.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.13300","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T19:13:18Z","timestamp":1492629198000},"page":"878-884","source":"Crossref","is-referenced-by-count":13,"title":["Febrile status epilepticus due to respiratory syncytial virus infection"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0168-5641","authenticated-orcid":false,"given":"Kazuhiro","family":"Uda","sequence":"first","affiliation":[{"name":"Department of Pediatrics Asahi General Hospital Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Kitazawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Asahi General Hospital Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70546-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01106.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2006.06.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-013-8368-9"},{"key":"e_1_2_8_6_1","first-page":"141","article-title":"Respiratory syncytial virus infection in children","volume":"83","author":"Dawson\u2010Caswell M","year":"2011","journal-title":"Am. 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