{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:54:54Z","timestamp":1792457694077,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T00:00:00Z","timestamp":1499990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Similarly to psoriasis in adults, recent research has linked psoriasis to several comorbidities in children. The aim of this study was therefore to describe comorbidities associated with pediatric psoriasis, to investigate their relationship with psoriasis characteristics and severity, and to perform a review of the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was performed on a sample of Moroccan children with psoriasis, in 2014\u20132016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 64 pediatric psoriasis patients had metabolic comorbidities in association with psoriasis; 20 children had non\u2010metabolic comorbidities; and 76 children had no comorbidity. The metabolic comorbidities were as follows: abdominal obesity, 40% (<jats:italic>n<\/jats:italic> = 64); overweight, 12.5% (<jats:italic>n<\/jats:italic> = 20); metabolic syndrome, 3.7% (<jats:italic>n<\/jats:italic> = 6); and dyslipidemia, 3.1% (<jats:italic>n<\/jats:italic> = 5); the non\u2010metabolic comorbidities were atopy, 4.3% (<jats:italic>n<\/jats:italic> = 7); epilepsy, 3.1% (<jats:italic>n<\/jats:italic> = 5); celiac disease, 1.8% (<jats:italic>n<\/jats:italic> = 3); vitiligo, 1.8% (<jats:italic>n<\/jats:italic> = 3); alopecia ariata, 0.6% (<jats:italic>n<\/jats:italic> = 1); and valvular cardiopathy, 0.6% (<jats:italic>n<\/jats:italic> = 1). No cases of diabetes mellitus, obesity, or high blood pressure were recorded. Significant factors associated with metabolic comorbidity were extended psoriasis vulgaris &gt;10% (<jats:italic>P<\/jats:italic> = 0.01; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 2.19), severe psoriasis especially pustular and erythroderma (<jats:italic>P<\/jats:italic> = 0.018; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 2), nail involvement (<jats:italic>P<\/jats:italic> = 0.016; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.5), face involvement (<jats:italic>P<\/jats:italic> = 0.01; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1,59), resistance to topical treatment (<jats:italic>P<\/jats:italic> = 0.003; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 2.5) and alteration of quality of life (<jats:italic>P<\/jats:italic> = 0.02; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1,7). There was no significant risk factor associated with non\u2010metabolic comorbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Given the frequent association of pediatric psoriasis with many disorders, these comorbidities should be investigated and identified so that they can be taken into account in the management of psoriasis in order to avoid treatment failure. Regular follow up should be carried out in patients at risk of metabolic comorbidity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13309","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T08:08:50Z","timestamp":1493366930000},"page":"923-928","source":"Crossref","is-referenced-by-count":17,"title":["Pediatric psoriasis: Should we be concerned with comorbidity? 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