{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T07:50:59Z","timestamp":1759564259129,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,7,9]],"date-time":"2017-07-09T00:00:00Z","timestamp":1499558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fetal hypoxia from intrapartum events can lead to absent heart rate (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) or bradycardia at birth requiring aggressive neonatal resuscitation. Neonatal resuscitation guidelines do not differentiate bradycardia (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> &lt;100 beats\/min) from absent <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> at birth. Given that <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> is the primary determinant of resuscitation, we hypothesize that infants with no <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> at 1 min would require more extensive resuscitation with worse clinical outcome than infants with bradycardia at 1 min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was performed in infants born between 1 January 2000 and 31 December 2015 with no <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> at 1 min (defined as Apgar score [<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>] = 0 at 1 min; absent <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> [<jats:styled-content style=\"fixed-case\">AHR<\/jats:styled-content>] group) or bradycardia at 1 min (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> = 1 at 1 min). Patient demographics, resuscitation characteristics and clinical outcomes were analyzed in both the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Apgar score was significantly lower in the <jats:styled-content style=\"fixed-case\">AHR<\/jats:styled-content> group over time. The <jats:styled-content style=\"fixed-case\">AHR<\/jats:styled-content> group had significantly higher rates of intubation, chest compression (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>) and i.v. epinephrine (i.v. epi); resulting in longer duration of <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>, time to <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> &gt; 100 beats\/min and duration of resuscitation. Systematic hypotension and death were higher in the <jats:styled-content style=\"fixed-case\">AHR<\/jats:styled-content> group. On logistic regression, <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> and cord <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> were significantly correlated with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> = 0 at 1 min. Gestational age, birthweight, <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> at 5 min, cord <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> and first blood gas <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> after resuscitation were related to overall mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Infants with <jats:styled-content style=\"fixed-case\">AHR<\/jats:styled-content> at 1 min did worse than infants with bradycardia. Education focused on effective positive pressure ventilation and early use of i.v. epinephrine is essential for successful resuscitation of the depressed newborn.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13310","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T08:16:38Z","timestamp":1493367398000},"page":"891-897","source":"Crossref","is-referenced-by-count":6,"title":["Impact of bradycardia or asystole on neonatal cardiopulmonary resuscitation at birth"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0950-2608","authenticated-orcid":false,"given":"Vasantha HS","family":"Kumar","sequence":"first","affiliation":[{"name":"Division of Neonatology Women and Children's Hospital of Buffalo Buffalo New York USA"},{"name":"University at Buffalo Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Skrobacz","sequence":"additional","affiliation":[{"name":"Division of Neonatology Women and Children's Hospital of Buffalo Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changxing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Biostatistics School of Public Health and Health Professions Buffalo New York USA"},{"name":"University at Buffalo Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0416"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1995.02170130022005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000276"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.10.877"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000267"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.971119"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199912000-00024"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.07.041"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0349"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.3.428"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0913"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2012.07.035"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-0784"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13089"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2015.03.008"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.025459"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13310","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.13310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T19:25:08Z","timestamp":1694719508000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.13310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,9]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/ped.13310"],"URL":"https:\/\/doi.org\/10.1111\/ped.13310","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"type":"print","value":"1328-8067"},{"type":"electronic","value":"1442-200X"}],"subject":[],"published":{"date-parts":[[2017,7,9]]}}}