{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:57:41Z","timestamp":1773331061819,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T00:00:00Z","timestamp":1499990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to ascertain if prospective determination of specific gut hormones and growth factors could predict bowel adaptation in children with short bowel syndrome (<jats:styled-content style=\"fixed-case\">SBS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied independence from parenteral nutrition (<jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content>) as the short\u2010term result and discontinuation of enteral nutrition (<jats:styled-content style=\"fixed-case\">EN<\/jats:styled-content>) as the long\u2010term result from a retrospective chart review of seven patients with <jats:styled-content style=\"fixed-case\">SBS<\/jats:styled-content>, who were managed in the absence of growth retardation. The correlation between increased number of enteral feeds or enteral nutrients and fasting serum gastrin, glucagon\u2010like peptide 2 (<jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\u20102), citrulline, and D\u2010amino acid oxidase (<jats:styled-content style=\"fixed-case\">DAO<\/jats:styled-content>) activity was analyzed. Five patients were weaned from <jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content>, and two from <jats:styled-content style=\"fixed-case\">EN<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fasting serum gastrin was significantly higher and serum <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\u20102 lower in the <jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content>\u2010dependent patients than in the patients weaned from <jats:styled-content style=\"fixed-case\">EN<\/jats:styled-content>. The upper limit of fasting serum gastrin for <jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content> independence and for <jats:styled-content style=\"fixed-case\">EN<\/jats:styled-content> independence was 300 and 200 pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>, respectively. The lower limit of fasting serum citrulline for <jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content> independence was 15 \u03bcmol\/L. The relationship between serum citrulline and <jats:styled-content style=\"fixed-case\">DAO<\/jats:styled-content> and the course of bowel adaptation, however, was poor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum citrulline is a predictor of <jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content> independence in children with <jats:styled-content style=\"fixed-case\">SBS<\/jats:styled-content>. Fasting serum gastrin and <jats:styled-content style=\"fixed-case\">GLP<\/jats:styled-content>\u20102 are indicators for adaptation of the residual intestine, but this was a small study and further larger prospective trials are required to confirm these results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13315","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T15:54:55Z","timestamp":1494950095000},"page":"911-916","source":"Crossref","is-referenced-by-count":9,"title":["Markers of enteral adaptation in pediatric short bowel syndrome"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1241-509X","authenticated-orcid":false,"given":"Masahiro","family":"Chiba","sequence":"first","affiliation":[{"name":"Division of Pediatric Surgery Department of Surgery Showa University Hospital Shinagawa Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Sanada","sequence":"additional","affiliation":[{"name":"Nutrition Support Team Showa University Fujigaoka Hospital Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Toki","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery Department of Surgery Showa University Hospital Shinagawa Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000171433"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80261-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclnm.2009.06.021"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-007-0878-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.4.559"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000134250.80492.EC"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.12.027"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2008.02.005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31819986da"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109836"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1054\/clnu.2000.0369"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-011-0813-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/08941939209012447"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.10.066"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02088237"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.7.5840"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2013.03.016"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00807268"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(90)90154-K"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607196020004275"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13315","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.13315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T19:25:18Z","timestamp":1694719518000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.13315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,14]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/ped.13315"],"URL":"https:\/\/doi.org\/10.1111\/ped.13315","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,14]]}}}