{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:23:05Z","timestamp":1762917785561},"reference-count":9,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,8,13]],"date-time":"2017-08-13T00:00:00Z","timestamp":1502582400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Kleine\u2013Levin syndrome is a rare sleep disorder of unknown etiology characterized by repetitive episodes of hypersomnia between asymptomatic periods. We report the case of a 13\u2010year\u2010old girl who presented with drowsiness triggered by influenza A as the first episode. Magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) on day 6 showed transient reduction of diffusion in the corpus callosum splenium. The patient was diagnosed with encephalopathy with a reversible splenial lesion. The symptoms resolved after 10\u00a0days, but additional episodes of hypersomnia lasting 5\u201310\u00a0days occurred 1, 5, 6, 11, 13, and 25\u00a0months after the first episode. <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> during hypersomnia indicated no lesions, and sleep duration and cognition were normal between episodes. The patient was diagnosed with Kleine\u2013Levin syndrome. Electroencephalographic and clinical findings during the first episode were similar to those during the other episodes. Encephalopathy with a splenial lesion and Kleine\u2013Levin syndrome may have similar pathological mechanisms causing a disturbance in consciousness.<\/jats:p>","DOI":"10.1111\/ped.13326","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T01:00:14Z","timestamp":1502672414000},"page":"929-931","source":"Crossref","is-referenced-by-count":7,"title":["Kleine\u2013Levin syndrome elicited by encephalopathy with reversible splenial lesion"],"prefix":"10.1111","volume":"59","author":[{"given":"Masaru","family":"Takayanagi","sequence":"first","affiliation":[{"name":"Division of Pediatrics Sendai City Hospital Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Okabe","sequence":"additional","affiliation":[{"name":"Okabe Clinic Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuya","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Nankodai Yamamoto Children's Clinic Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juri","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Sendai City Hospital Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikio","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Sendai City Hospital Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Sendai City Hospital Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Ohura","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Sendai City Hospital Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,13]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"International Classification of Sleep Disorders","author":"American Academy of Seep Medicine","year":"2014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70187-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.01.009"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000144274.12174.CB"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2009.02.012"},{"key":"e_1_2_7_7_1","first-page":"19","article-title":"Kleine\u2010Levin syndrome: a review","volume":"6","author":"Miglis MG","year":"2014","journal-title":"Nat. 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