{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:53:23Z","timestamp":1761630803614,"version":"3.37.3"},"reference-count":8,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,10,29]],"date-time":"2017-10-29T00:00:00Z","timestamp":1509235200000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16K19623"],"award-info":[{"award-number":["JP16K19623"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Abstract<\/jats:title>Rituximab (RTX<\/jats:styled-content>), a specific antibody to human CD<\/jats:styled-content>20, has been successfully used to treat intractable nephrotic syndrome (NS<\/jats:styled-content>). Recent studies have suggested a direct effect of RTX<\/jats:styled-content> on podocytes by targeting sphingomyelinase phosphodiesterase acid\u2010like 3b (SMPDL<\/jats:styled-content>\u20103b). Thus, we examined the urinary excretion of SMPDL<\/jats:styled-content>\u20103b as well as its immunoreactivity in biopsy specimens from children with intractable NS<\/jats:styled-content>. Urine samples from six patients (five with minimal\u2010change NS<\/jats:styled-content> and one with focal segmental glomerulosclerosis) and from four healthy adults were examined. Glomerular immunoreactivity and urinary excretion of SMPDL<\/jats:styled-content>3b in proteinuric NS<\/jats:styled-content> patients decreased compared with controls. Interestingly, urine samples obtained from the same patients at the remission stage after RTX<\/jats:styled-content> treatment showed an increase in urinary SMPDL<\/jats:styled-content>\u20103b excretion compared with the proteinuric stage. Urinary excretion level of SMPDL<\/jats:styled-content>\u20103b could thus be used to predict the clinical efficacy of RTX<\/jats:styled-content> treatment in NS<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/ped.13355","type":"journal-article","created":{"date-parts":[[2017,10,29]],"date-time":"2017-10-29T23:55:15Z","timestamp":1509321315000},"page":"1112-1115","source":"Crossref","is-referenced-by-count":10,"title":["Urinary excretion of sphingomyelinase phosphodiesterase acid\u2010like 3b in children with intractable nephrotic syndrome"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4379-5857","authenticated-orcid":false,"given":"Shojiro","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Pediatrics Hirosaki University Hospital Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Tsugawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hirosaki University Hospital Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushi","family":"Tsuruga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hirosaki University Hospital Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadaatsu","family":"Imaizumi","sequence":"additional","affiliation":[{"name":"Department of Vascular Biology Hirosaki University Graduate School of Medicine Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hirosaki University Hospital Hirosaki Japan"},{"name":"Department of School Health Science Faculty of Education Hirosaki University Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002231"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.05.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013040363"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12737"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013111213"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201600618R"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08500815"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200112849"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13355","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.13355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T16:38:30Z","timestamp":1694709510000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.13355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":8,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/ped.13355"],"URL":"https:\/\/doi.org\/10.1111\/ped.13355","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"type":"print","value":"1328-8067"},{"type":"electronic","value":"1442-200X"}],"subject":[],"published":{"date-parts":[[2017,10]]}}}