{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:35:55Z","timestamp":1777592155236,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T00:00:00Z","timestamp":1506988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to determine the frequency of central nervous system comorbidities in children with neurofibromatosis type 1 (<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a nationwide survey to investigate neurological comorbidities in 3\u201315\u2010year\u2010old children with <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 in Japan by sending questionnaires to pediatricians and pediatric neurologists. A secondary questionnaire was sent to the parents of identified <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 patients to assess neurological comorbidities including headache, attention deficit\u2013hyperactivity disorder (<jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>) Rating Scale (<jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>), and the Social Responsiveness Scale 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The primary survey identified 760 <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 patients, and the parents of 565 patients were sent the secondary questionnaire. The parental response rate was 25.7% (145; 63 girls, 81 boys, one unspecified). Among the patients, 42.9% (55\/128; 35 girls, 20 boys) were reported to exhibit intellectual problems. On the <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>, 40.2% (47\/117) of <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1 patients aged 6\u201315 had <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> score &gt;93rd percentile), with a rate of 47.7% in boys and 30.8% in girls. Furthermore, 20.2% of patients had suspected autism spectrum disorder (29\/143; 10 girls, 19 boys), with Social Responsiveness Scale score \u226576. Headache was reported by 49.6% (61\/123) of children over 5 years old, and 25.2% (31\/123; 10 girls, 21 boys) reported migraine. Other neurological comorbidities included 20 cases of epilepsy (13.8%), 11 cases of optic nerve glioma (7.6%), five cases of brain tumor (3.4%), six cases of cerebrovascular disease (4.1%), and two cases of hydrocephalus (1.4%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intellectual problems, <jats:styled-content style=\"fixed-case\">ADHD<\/jats:styled-content>, autism spectrum disorder, and migraine are major neurological comorbidities in <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>1.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13388","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T18:02:37Z","timestamp":1502388157000},"page":"70-75","source":"Crossref","is-referenced-by-count":31,"title":["Neurological comorbidity in children with neurofibromatosis type 1"],"prefix":"10.1111","volume":"60","author":[{"given":"Keiko","family":"Hirabaru","sequence":"first","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Saga University Nabeshima Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8667-836X","authenticated-orcid":false,"given":"Muneaki","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Saga University Nabeshima Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33139"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12043"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1868"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37186"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12375"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520290115023"},{"key":"e_1_2_8_8_1","volume-title":"ADHD\u2010Rating Scale 4","author":"DuPaul G","year":"2008"},{"key":"e_1_2_8_9_1","first-page":"317","article-title":"[Standardization of the Japanese Versions of the ADHD\u2010RS.] Clin","volume":"58","author":"Tanaka Y","year":"2016","journal-title":"Psychiatry"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2013.11.004"},{"key":"e_1_2_8_11_1","volume-title":"Social Responsiveness Scale","author":"Constantino J","year":"2012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000179303.72345.ce"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2006.tb01268.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2006.01.006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023035426642"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-012-0135-8"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2016.08.023"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-3217"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32280"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-014-2323-3"},{"key":"e_1_2_8_22_1","doi-asserted-by":"crossref","first-page":"E8.1","DOI":"10.3171\/2009.11.FOCUS09221","article-title":"Neurofibromatosis type 1 and tumorigenesis: Molecular mechanisms and therapeutic implications","volume":"28","author":"Gottfried ON","year":"2010","journal-title":"Neurosurg. 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