{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:49:41Z","timestamp":1781646581434,"version":"3.54.5"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T00:00:00Z","timestamp":1513728000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The diagnosis of biliary atresia (<jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>) is still challenging. The aim of this study was to analyze the clinical features and parameters that contribute to a diagnosis of <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 2000 to December 2013, 37 patients who underwent operative cholangiography were evaluated retrospectively. The patients were divided into two groups: a <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> group, and a group with other cholestatic diseases (non\u2010<jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> group). The demographic data and preoperative liver function test results were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 37 patients, 29 patients were confirmed to have <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>. Age at operation was not significantly different between the two groups (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.77). On preoperative liver function tests, only the level of \u03b3\u2010glutamyl transpeptidase (\u03b3\u2010<jats:styled-content style=\"fixed-case\">GTP<\/jats:styled-content>) was significantly higher in the <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> group (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.015). The predominant non\u2010<jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> disease was inspissated bile syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>). In the <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> patients, the jaundice was relieved after lavage of the biliary tree.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The preoperative differentiation of cholestasis is difficult based on laboratory data and imaging. Preoperative \u03b3\u2010<jats:styled-content style=\"fixed-case\">GTP<\/jats:styled-content> may be useful for diagnosing <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content>, but operative cholangiography should be performed when <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> is suspected and cannot be ruled out by other methods, given that the most common non\u2010<jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> disease may be <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13392","type":"journal-article","created":{"date-parts":[[2017,8,12]],"date-time":"2017-08-12T14:16:37Z","timestamp":1502547397000},"page":"1261-1265","source":"Crossref","is-referenced-by-count":7,"title":["Parameters that help to differentiate biliary atresia from other diseases"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2998-9679","authenticated-orcid":false,"given":"Makoto","family":"Hayashida","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Reproductive and Developmental Medicine Graduate School of Medical Sciences Kyushu University Higashi, Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiharu","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Reproductive and Developmental Medicine Graduate School of Medical Sciences Kyushu University Higashi, Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Reproductive and Developmental Medicine Graduate School of Medical Sciences Kyushu University Higashi, Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genshiro","family":"Esumi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Reproductive and Developmental Medicine Graduate School of Medical Sciences Kyushu University Higashi, Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Yoshimaru","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Reproductive and Developmental Medicine Graduate School of Medical Sciences Kyushu University Higashi, Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Yanagi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Reproductive and Developmental Medicine Graduate School of Medical Sciences Kyushu University Higashi, Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Reproductive and Developmental Medicine Graduate School of Medical Sciences Kyushu University Higashi, Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Reproductive and Developmental Medicine Graduate School of Medical Sciences Kyushu University Higashi, Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.14-2-e63"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.08.032"},{"key":"e_1_2_8_4_1","first-page":"115","article-title":"Biliary atresia","volume":"1","author":"Ohi R","year":"1992","journal-title":"Semin. 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