{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:41:51Z","timestamp":1765294911677,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T00:00:00Z","timestamp":1511913600000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The developmental process of bronchopulmonary dysplasia (BPD<\/jats:styled-content>) is not identical between very preterm infants born small for gestational age (SGA<\/jats:styled-content>) and those born appropriate for gestational age (AGA<\/jats:styled-content>). In this study, we compared the pattern of the inflammatory response in infants of each group, by measuring urinary \u03b22\u2010microglobulin (U\u03b22M) as an alternative, concise, and less\u2010invasive biomarker.<\/jats:p><\/jats:sec>Methods<\/jats:title>U\u03b22M and clinical details were examined at birth and at 4\u00a0weeks of age in 146 very preterm infants.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 57 infants diagnosed with BPD<\/jats:styled-content>, 18 were SGA<\/jats:styled-content>, and 39 were AGA<\/jats:styled-content>. U\u03b22M at birth was significantly lower in SGA BPD<\/jats:styled-content> infants than in AGA BPD<\/jats:styled-content> infants, but it increased with time. The prevalence of chorioamnionitis (CAM<\/jats:styled-content>) was significantly lower in SGA BPD<\/jats:styled-content> infants than in AGA BPD<\/jats:styled-content> infants, while that of pregnancy\u2010induced hypertension was the opposite.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Exposure to prenatal factors other than CAM<\/jats:styled-content> may sensitize fetal lungs to become vulnerable to postnatal inflammation in very preterm SGA<\/jats:styled-content> infants with BPD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13407","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T07:42:42Z","timestamp":1503042162000},"page":"1169-1173","source":"Crossref","is-referenced-by-count":4,"title":["Urinary \u03b22\u2010microglobulin and bronchopulmonary dysplasia: Trends in preterm infants"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2287-4430","authenticated-orcid":false,"given":"Yoshio","family":"Shima","sequence":"first","affiliation":[{"name":"Department of Neonatal Medicine Nippon Medical School Musashikosugi Hospital Kanagawa Japan"},{"name":"Department of Pediatrics Japanese Red Cross Maternity Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakae","family":"Kumasaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Japanese Red Cross Maternity Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Nishimaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yokohama City University Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2959"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000078953"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2007.00780.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68615-7"},{"key":"e_1_2_8_6_1","first-page":"4","article-title":"Comparisons of mortality and pre\u2010discharge respiratory outcomes in small\u2010for\u2010gestational\u2010age and appropriate\u2010for\u2010gestational\u2010age premature infants","volume":"8","author":"Sharma P","year":"2004","journal-title":"BMC Pediatr."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2012.201"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2014.03.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1084-2756(02)00190-2"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.068544"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70272-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(97)00236-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70299-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.10.018"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.129"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(03)00249-X"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2008.00988.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"e_1_2_8_19_1","first-page":"624","article-title":"[Birth size standards by gestational age for Japanese neonates.]","volume":"34","author":"Ogawa Y","year":"1998","journal-title":"J. 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