{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:43:21Z","timestamp":1780343001790,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T00:00:00Z","timestamp":1508803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Given that preterm infants are born at a time of rapid fetal growth, they are at risk of deficiency of essential nutrients for brain development, including zinc (Zn) and copper (Cu). This study evaluate the relationship between serum Cu or Zn, gestational age (<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>) and anthropometric parameters at birth in preterm infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of infants &lt;35\u00a0weeks\u2019 <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> from January 2010 to August 2012. We collected the data from medical records of 59 preterm infants at birth with regard to <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>, anthropometric parameters, and serum Cu and Zn levels. Correlation of Cu, Zn, and <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> with anthropometric parameters at birth was then done.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Zn was inversely correlated with <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>, bodyweight (<jats:styled-content style=\"fixed-case\">BW<\/jats:styled-content>), body length (<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>), and head circumference (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>), and Cu was inversely correlated with the standard deviation (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) score for <jats:styled-content style=\"fixed-case\">BW<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> BL<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>. On stepwise multiple regression analysis, <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> was a significant independent predictor of Zn level, and <jats:styled-content style=\"fixed-case\">HC SD<\/jats:styled-content> score was a significant independent predictor of Cu level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prematurity influences Zn, and intrauterine head growth restriction influences Cu at birth in preterm infants. Further research is needed to evaluate the relationship between intrauterine growth restriction and brain Cu metabolism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13409","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T15:54:51Z","timestamp":1504022091000},"page":"1165-1168","source":"Crossref","is-referenced-by-count":17,"title":["Association of zinc and copper with clinical parameters in the preterm newborn"],"prefix":"10.1111","volume":"59","author":[{"given":"Chiharu","family":"Kojima","sequence":"first","affiliation":[{"name":"Department of Pediatrics Juntendo University Faculty of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2532-8910","authenticated-orcid":false,"given":"Hiromichi","family":"Shoji","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naho","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Juntendo University Faculty of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Juntendo University Faculty of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Hisata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Juntendo University Faculty of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000358467"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1998.tb01531.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2013.08.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.5.1344S"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006868305749"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2119\/2008-00033.Prasad"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-159-40279"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80013-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-010-0145-8"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1985.65.2.238"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.08.070188.001315"},{"key":"e_1_2_7_13_1","first-page":"67","article-title":"Assessment of trace element status in humans","volume":"13","author":"Gibson RS","year":"1989","journal-title":"Prog. Food Nutr. Sci."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533612461531"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1093\/clinchem\/35.4.552","article-title":"Sensitive, direct colorimetric assay for copper in serum","volume":"35","author":"Abe A","year":"1989","journal-title":"Clin. Chem."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(82)90083-3"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12331"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02784053"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(02)00024-5"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2005.01.007"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1385\/BTER:73:2:127"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198809000-00010"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02723246"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/clinchem\/38.1.141","article-title":"Association between magnesium, calcium, phosphorus, copper, and zinc in umbilical cord plasma and erythrocytes, and the gestational age and growth variables of full\u2010term newborns","volume":"38","author":"Speich M","year":"1992","journal-title":"Clin. Chem."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075627"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02831358"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2016.06.010"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.10.006"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.10.056"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.4065\/81.10.1371"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.30.051606.094232"},{"key":"e_1_2_7_32_1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1542\/peds.52.4.525","article-title":"The syndrome of neonatal copper deficiency","volume":"52","author":"Ashkenazi A","year":"1973","journal-title":"Pediatrics"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13409","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.13409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T21:04:16Z","timestamp":1694725456000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.13409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,24]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/ped.13409"],"URL":"https:\/\/doi.org\/10.1111\/ped.13409","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,24]]}}}