{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:19:15Z","timestamp":1740125955289,"version":"3.37.3"},"reference-count":10,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T00:00:00Z","timestamp":1511913600000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H06971"],"award-info":[{"award-number":["16H06971"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Surfactant replacement therapy is widely used for treating neonatal respiratory distress syndrome, but insufficient evidence is available on the use of Surfacten\u00ae (S\u2010<jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content>). This study investigated the inadvertent loss of S\u2010<jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content> during instillation via feeding catheters with different bore sizes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this bench\u2010based study, we measured the weight of syringes and tubes before and after surfactant treatment using a high\u2010accuracy balance, and determined the amount of S\u2010<jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content> lost in tubes. We injected 120\u00a0mg of S\u2010<jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content> suspended in 4 or 3\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> into tubes followed with or without air boluses. Experiments were performed in triplicate. Percent weight loss of S\u2010<jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content> in each tube was calculated with or without air boluses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Percent weight loss of S\u2010<jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content> was significantly higher in larger\u2010bore tubes (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01, overall ANOVA), and was significantly lower after air bolus flushing in 3 Fr, 4 Fr, and 5 Fr tubes (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.005, respectively). The 3 <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> S\u2010<jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content> suspensions had a significantly higher percent loss than the 4 <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> S\u2010<jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content> suspensions when using 4 Fr and 5 Fr tubes, and the 5 Fr closed system (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Routine air bolus flushing effectively reduces S\u2010<jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content> loss in tubes. The 3\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> S\u2010<jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content> suspensions appear to be more susceptible to inadvertent S\u2010<jats:styled-content style=\"fixed-case\">TA<\/jats:styled-content> loss during instillation. Therefore, caution is warranted for this procedure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13412","type":"journal-article","created":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T16:52:45Z","timestamp":1503939165000},"page":"1174-1177","source":"Crossref","is-referenced-by-count":6,"title":["Loss of Surfacten<sup>\u00ae<\/sup> during bolus administration with a feeding catheter"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9913-6447","authenticated-orcid":false,"given":"Kazumichi","family":"Fujioka","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jumpei","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Yamana","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumoto","family":"Iijima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5685-2670","authenticated-orcid":false,"given":"Ichiro","family":"Morioka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)90489-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2371"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60986-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-0603"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1542\/peds.86.5.753","article-title":"Surfactant replacement therapy with a single postventilatory dose of a reconstituted bovine surfactant in preterm neonates with respiratory distress syndrome: final analysis of a multicenter, double\u2010blind, randomized trial and comparison with similar trials. The Surfactant\u2010TA Study Group","volume":"86","author":"Fujiwara T","year":"1990","journal-title":"Pediatrics"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199304000-00019"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-003-1276-x"},{"key":"e_1_2_8_9_1","first-page":"209","article-title":"Surfactant inadvertent loss using feeding catheters or endotracheal tubes","volume":"31","author":"Luca D","year":"2014","journal-title":"Am. J. Perinatol."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-310299"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2005.20.4.591"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.13412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T21:04:13Z","timestamp":1694725453000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.13412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/ped.13412"],"URL":"https:\/\/doi.org\/10.1111\/ped.13412","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"type":"print","value":"1328-8067"},{"type":"electronic","value":"1442-200X"}],"subject":[],"published":{"date-parts":[[2017,11]]}}}