{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:07:52Z","timestamp":1791986872863,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H20\u2010Kodomo\u2010007"],"award-info":[{"award-number":["H20\u2010Kodomo\u2010007"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H23\u2010Jisedai\u2010Ippan\u2010001"],"award-info":[{"award-number":["H23\u2010Jisedai\u2010Ippan\u2010001"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H25\u2010Jisedai\u2010Shitei\u2010003"],"award-info":[{"award-number":["H25\u2010Jisedai\u2010Shitei\u2010003"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to evaluate the outcome of congenital cytomegalovirus (<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>) infection identified on urine\u2010filter screening assay at &gt;2 years\u2019 follow up, and to observe the clinical outcomes after anti\u2010<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty of 72 congenital <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> patients were enrolled and clinically observed for &gt;2 years. Forty\u2010three were asymptomatic at birth; seven were symptomatic at birth but untreated with anti\u2010<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> drugs; and 10 were symptomatic and treated with anti\u2010<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 43 asymptomatic patients, three developed hearing loss or language disability for which association with congenital <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> has been repeatedly reported, and two had neurological sequelae of which the etiology was unclear, indicating that the rate of <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>\u2010associated late\u2010onset sequelae was 7\u201312%. All seven symptomatic infants without treatment developed sequelae, while three of the 10 treated patients were free from any sequelae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The rate of late\u2010onset sequelae observed in Japan is similar to that reported in the <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content> and Europe. The treatment of symptomatic patients with antiviral agents results in favorable clinical outcomes. Thus, newborn urine\u2013filter paper screening of congenital <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infection is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13433","type":"journal-article","created":{"date-parts":[[2017,10,15]],"date-time":"2017-10-15T14:34:41Z","timestamp":1508078081000},"page":"57-62","source":"Crossref","is-referenced-by-count":27,"title":["Congenital cytomegalovirus in Japan: More than 2 year follow up of infected newborns"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4221-2031","authenticated-orcid":false,"given":"Shin","family":"Koyano","sequence":"first","affiliation":[{"name":"Department of Pediatrics Asahikawa Medical University Hokkaido Japan"},{"name":"Ujiie Memorial Clinic for Children Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5685-2670","authenticated-orcid":false,"given":"Ichiro","family":"Morioka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokyo University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Moriuchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nagasaki University Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimisato","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Fukushima Medical University Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Maternal and Perinatal Services National Center for Child Health and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2847-7682","authenticated-orcid":false,"given":"Tetsushi","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fujita Health University Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideto","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kobe University Graduate School of Medicine Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Suzutani","sequence":"additional","affiliation":[{"name":"Department of Microbiology Fukushima Medical University Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Virology I National Institute of Infectious Diseases Tokyo Japan"},{"name":"Department of Microbiology and Immunology Gifu Pharmaceutical University Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Japanese Congenital Cytomegalovirus Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182897c36"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/598506"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/511981"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.10088"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2011.653445"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2011-000118"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30143-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1790"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit018"},{"key":"e_1_2_8_11_1","first-page":"1","article-title":"Anti\u2010viral therapy for congenital cytomegalovirus infection: Pharmacokinetics, efficacy and side effects","volume":"27","author":"Mareri A","year":"2015","journal-title":"J. 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