{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:59:11Z","timestamp":1753883951019,"version":"3.37.3"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T00:00:00Z","timestamp":1513209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Glutaryl carnitine (C5<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>) in dried blood spots is used as a biomarker for glutaric aciduria type 1 (<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>\u20101) screening. C5<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>, however, is the only screening marker for this condition, and various pathological conditions may interfere with C5<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> metabolism. Recently, C5<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> elevation has been reported in cases of renal insufficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Five patients who were positive for <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>\u20101 on newborn screening with tandem mass spectrometry between September 2012 and March 2015 at Kobe University Hospital were enrolled in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>\u20101 was not confirmed on urinary organic acids analysis in any of the patients. C5<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> decreased immediately in four patients, but one patient, who had high C5<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> for at least 4 months, was diagnosed with bilateral renal hypoplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the case of persistently elevated C5<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>, renal insufficiency should be considered as a differential diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13438","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T16:28:51Z","timestamp":1508776131000},"page":"67-69","source":"Crossref","is-referenced-by-count":6,"title":["Renal insufficiency mimicking glutaric acidemia type 1 on newborn screening"],"prefix":"10.1111","volume":"60","author":[{"given":"Masaaki","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9846-4142","authenticated-orcid":false,"given":"Hiroyuki","family":"Awano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Bo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumi","family":"Tomioka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Ninchouji","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Nagase","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Yagi","sequence":"additional","affiliation":[{"name":"Nikoniko House Center Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5685-2670","authenticated-orcid":false,"given":"Ichiro","family":"Morioka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hyogo College of Medicine Nishinomiya Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Takeshima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shimane University School of Medicine Izumo Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumoto","family":"Iijima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-008-0912-z"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-006-0284-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:BOLI.0000037343.90450.8d"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-009-9017-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80479-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.171.6.9843315"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2012.05.024"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:BOLI.0000045769.96657.af"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.01.014"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.04.019"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13438","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.13438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T11:51:56Z","timestamp":1694692316000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.13438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,14]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/ped.13438"],"URL":"https:\/\/doi.org\/10.1111\/ped.13438","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"type":"print","value":"1328-8067"},{"type":"electronic","value":"1442-200X"}],"subject":[],"published":{"date-parts":[[2017,12,14]]}}}