{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:41:50Z","timestamp":1790959310783,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to determine whether serum immunoglobulin A\/complement factor 3 (IgA\/C3) ratio and glomerular C3 staining predict outcome in IgA nephropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected data for 44 IgA nephropathy children treated with multi\u2010drug combination therapy. The children were retrospectively divided into four groups based on serum IgA\/C3 ratio and glomerular C3 staining: group A, IgA\/C3 ratio &gt;2.68 (median) and glomerular C3 staining \u22652.0, n\u00a0=\u00a09; group B, IgA\/C3 ratio &gt;2.68 and glomerular C3 staining &lt;2.0, n\u00a0=\u00a07; group C, IgA\/C3 ratio &lt;2.68 and glomerular C3 staining \u22652.0, n\u00a0=\u00a07; and group D, IgA\/C3 ratio &lt;2.68 and glomerular C3 staining &lt;2.0, n\u00a0=\u00a021. Clinical features; pathology at the first and second renal biopsy and at the latest follow up; and prognosis were analyzed for the four groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the most recent follow up, urinary protein excretion, incidence of hematuria, and serum creatinine in group A were all higher than in group D. At the second biopsy, crescent absence\/presence ratio; mesangial hypercellularity, segmental glomerulosclerosis or adhesion, endocapillary hypercellularity, and tubular atrophy\/interstitial fibrosis as well as crescents and global glomerulosclerosis (<jats:styled-content style=\"fixed-case\">MESTCG<\/jats:styled-content>) score; and clonicity index in group A were higher than in group D. All patients in group D had normal urine, and the prevalence of persistent nephropathy in group A was higher than in group D.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum IgA\/C3 ratio and glomerular C3 staining can predict outcome in IgA nephropathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13461","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T08:03:13Z","timestamp":1511769793000},"page":"162-167","source":"Crossref","is-referenced-by-count":33,"title":["Serum IgA\/C3 and glomerular C3 staining predict severity of IgA nephropathy"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1380-7474","authenticated-orcid":false,"given":"Yukihiko","family":"Kawasaki","sequence":"first","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine Fukushima City Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine Fukushima City Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Ohara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine Fukushima City Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Suyama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine Fukushima City Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuaki","family":"Hosoya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fukushima Medical University School of Medicine Fukushima City Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"694","article-title":"Intercapillary deposits of IgA\u2010IgG","volume":"74","author":"Berger J","year":"1968","journal-title":"J. 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