{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:03:55Z","timestamp":1790643835993,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T00:00:00Z","timestamp":1516665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The aim of this study was to investigate whether the outcome of congenital diaphragmatic hernia (CDH<\/jats:styled-content>) in newborns can be predicted using left ventricular (LV<\/jats:styled-content>) diameter and estimated pulmonary artery pressure.<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients in the newborn unit in 2012\u20132016 were screened retrospectively. Echocardiographic measurements of 35 patients with isolated left lateral CDH<\/jats:styled-content> and 27 healthy newborns were compared in the first 24 h of life.<\/jats:p><\/jats:sec>Results<\/jats:title>Mean LV<\/jats:styled-content> end\u2010diastolic diameter (LVEDD<\/jats:styled-content>) and end\u2010systolic diameter (LVESD<\/jats:styled-content>), and LV<\/jats:styled-content> ejection fraction were significantly lower in the CDH<\/jats:styled-content> group. Moreover, tricuspid regurgitation (TR<\/jats:styled-content>) and pulmonary regurgitation (PR<\/jats:styled-content>) were significantly higher than in the controls (P<\/jats:italic> < 0.001). Six CDH<\/jats:styled-content> patients died within the next 40 days after birth. Mean LVEDD<\/jats:styled-content> and LVESD<\/jats:styled-content> were significantly lower in the CHD<\/jats:styled-content> patients who died compared with those who were discharged (P<\/jats:italic> < 0.001, P<\/jats:italic> = 0.016). Also, mean TR<\/jats:styled-content> and PR<\/jats:styled-content> (P<\/jats:italic> < 0.001) and the frequency of pulmonary hypertension (PH<\/jats:styled-content>; P<\/jats:italic> = 0.001) were significantly higher in these patients. On receiver operating characteristic analysis of the CDH<\/jats:styled-content> non\u2010survivors, LVEDD<\/jats:styled-content> < 11 mm (sensitivity, 100%; 95%CI<\/jats:styled-content>: 87.9\u2013100; specificity, 100%; 95%CI<\/jats:styled-content>: 54.1\u2013100) and TR<\/jats:styled-content> > 3.5 m\/s (sensitivity, 89.66%; 95%CI<\/jats:styled-content>: 72.6\u201397.7; specificity, 100%; 95%CI<\/jats:styled-content>: 54.1\u2013100) were associated with poor prognosis.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Decrease in LVEDD<\/jats:styled-content> and presence of PH<\/jats:styled-content> are associated with poor prognosis. Also, PH<\/jats:styled-content> was associated with mortality in CDH<\/jats:styled-content> patients. Thus, outcome may be predicted on careful echocardiographic evaluation of the LV<\/jats:styled-content> diameters and pulmonary pressure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13464","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T07:53:20Z","timestamp":1511769200000},"page":"122-126","source":"Crossref","is-referenced-by-count":13,"title":["Prognostic markers in congenital diaphragmatic hernia: Left ventricular diameter and pulmonary hypertension"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3007-1403","authenticated-orcid":false,"given":"Derya","family":"Karpuz","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology Faculty of Medicine University of Mersin Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Giray","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology Faculty of Medicine University of Mersin Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalcin","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Neonatology Faculty of Medicine University of Mersin Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olgu","family":"Hallioglu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology Faculty of Medicine University of Mersin Mersin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2000.8725"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.11.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.30834"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2003.11.010"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-307714"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2017.01.007"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.74.3.484"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2016.09.014"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2014.09.008"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-008-2266-x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(94)90726-9"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.5.1106"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2011.3"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.05.018"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2012.16"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(05)70109-3"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.12.036"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.11.046"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2016.46"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13464","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.13464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T11:54:24Z","timestamp":1694692464000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.13464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,23]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/ped.13464"],"URL":"https:\/\/doi.org\/10.1111\/ped.13464","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,23]]}}}