{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:07:56Z","timestamp":1790690876613,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Packed red blood cell transfusion is common in preterm neonates. Hepcidin acts as a negative feedback iron regulator. Iron parameters such as immature reticulocyte fraction (<jats:styled-content style=\"fixed-case\">IRF<\/jats:styled-content>) and high\u2010light\u2010scatter reticulocytes (<jats:styled-content style=\"fixed-case\">HLR<\/jats:styled-content>) are used to clarify iron metabolism. Very little is known about the regulation of hepcidin in preterm infants because most reports have evaluated prohepcidin. The aim of this study was therefore to evaluate serum hepcidin and establish hematological parameters in preterm infants after transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The subjects consisted of 19 newborns (10 boys) with mean gestational age 29.1 \u00b1 2.0 weeks, who had been transfused at the chronological age of 44.84 \u00b1 19.61 days. Blood sample was collected before the transfusion and thereafter at 5\u00a0days and at 1\u00a0month. Serum hepcidin and other iron parameters were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean serum hepcidin before and 5\u00a0days after transfusion was significantly different (5.5 \u00b1 5.1 vs 10 \u00b1 7.9 ng\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>respectively,<jats:italic>P<\/jats:italic>= 0.005).<jats:styled-content style=\"fixed-case\">IRF<\/jats:styled-content>and %<jats:styled-content style=\"fixed-case\">HLR<\/jats:styled-content>were also decreased significantly, 5\u00a0days after transfusion (0.4 \u00b1 0.2 vs 0.2 \u00b1 0.1,<jats:italic>P<\/jats:italic>= 0.009; 1.4 \u00b1 1.5% vs 0.5 \u00b1 0.4%,<jats:italic>P<\/jats:italic>= 0.012, respectively). Changes in hepcidin 5\u00a0days after transfusion were correlated significantly with changes in mean corpuscular hemoglobin (\u03b2, 0.13;<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>, 0.05;<jats:italic>P<\/jats:italic>= 0.017), total iron binding capacity (\u03b2, 3.74;<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>, 1.56;<jats:italic>P<\/jats:italic>= 0.016) and transferrin (\u03b2, 2.9,<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>, 1.4;<jats:italic>P<\/jats:italic>= 0.039).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum hepcidin concentration, along with<jats:styled-content style=\"fixed-case\">IRF<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">HLR<\/jats:styled-content>, are potentially useful in estimating pre\u2010 and post\u2010transfusion iron status. Larger studies are needed to evaluate the sensitivity and specificity of hepcidin compared with ordinary iron parameters in premature infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13478","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T13:47:28Z","timestamp":1513172848000},"page":"148-152","source":"Crossref","is-referenced-by-count":10,"title":["Post\u2010transfusion changes in serum hepcidin and iron parameters in preterm infants"],"prefix":"10.1111","volume":"60","author":[{"given":"Fotini","family":"Stripeli","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit P&amp;A Kyriakou Children's Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kapetanakis","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit P&amp;A Kyriakou Children's Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7859-6658","authenticated-orcid":false,"given":"Dimitris","family":"Gourgiotis","sequence":"additional","affiliation":[{"name":"Research Laboratory of Clinical Biochemistry\u2013Molecular Diagnostics P&amp;A Kyriakou Children's Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonis","family":"Drakatos","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry P&amp;A Kyriakou Children's Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Tsolia","sequence":"additional","affiliation":[{"name":"Second Department of Pediatrics National and Kapodistrian University of Athens P&amp;A Kyriakou Children's Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0476-6586","authenticated-orcid":false,"given":"Lydia","family":"Kossiva","sequence":"additional","affiliation":[{"name":"Second Department of Pediatrics National and Kapodistrian University of Athens P&amp;A Kyriakou Children's Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3282f73335"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215686"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-028787"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880010600629213"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22773"},{"key":"e_1_2_7_7_1","first-page":"727","article-title":"Hepcidin and iron\u2010loading anemias","volume":"91","author":"Nemeth E","year":"2006","journal-title":"Hematologica"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008923200"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104742"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409808102"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1159"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.35353"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/605435"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181b91667"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.12.030"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000437132"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2015-0361"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12035"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2010.01479.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.145961"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.5045\/kjh.2012.47.4.286"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-139915"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2009.03.039"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1982.tb09630.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-999651"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(01)00115-3"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.27232"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/09674845.2009.11730252"},{"issue":"438","key":"e_1_2_7_29_1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1651-2227.2002.tb02917.x","article-title":"Perinatal aspects of iron metabolism","volume":"91","author":"Rao R","year":"2002","journal-title":"Acta Paediatr."},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04516.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05931108"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13478","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.13478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T17:58:46Z","timestamp":1719683926000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.13478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/ped.13478"],"URL":"https:\/\/doi.org\/10.1111\/ped.13478","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2]]}}}