{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:19:54Z","timestamp":1740125994035,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The oxidation of low\u2010density lipoprotein (<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>; ox<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>) appears to play a key role in the early development of atherosclerosis. Increased serum antibodies against the ox<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> (anti\u2010ox<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> antibodies) have been found in adults with atherosclerotic disease, as well as in healthy adults. The clinical significance and its precise role (atherogenic or atheroprotective), however, have not yet been clarified. This aim of this study was therefore to evaluate anti\u2010ox<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> antibodies in healthy children and adolescents with and without hypercholesterolemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study involved 312 subjects, aged 4\u201318 years, 141 with <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> cholesterol (<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\u2010C) \u2265130 mg\/dL and 171 with acceptable <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\u2010C (&lt;110 mg\/dL). Total anti\u2010ox<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> antibodies, total cholesterol, <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\u2010C and high\u2010density lipoprotein cholesterol, triglycerides, apolipoproteins A1 and B, lipoprotein (a) and high\u2010sensitivity C\u2010reactive protein were measured in fasting serum. The anti\u2010ox<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> antibodies were measured on enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anti\u2010ox<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> antibodies were similar in the hypercholesterolemia and non\u2010hypercholesterolemia groups. Girls had significantly higher anti\u2010ox<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> antibodies compared with boys. There was no significant correlation of antibodies with age or body mass index. Increased apolipoprotein B was an important factor for lower anti\u2010ox<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> antibodies, while all other parameters had no significant association with anti\u2010ox<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In children and adolescents with hypercholesterolemia, total anti\u2010ox<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> antibodies cannot serve as a marker for risk for atherosclerosis or for future cardiovascular disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13501","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T12:00:01Z","timestamp":1514980801000},"page":"287-293","source":"Crossref","is-referenced-by-count":1,"title":["Influence of hypercholesterolemia on serum antibodies against oxidized <scp>LDL<\/scp> in children and adolescents"],"prefix":"10.1111","volume":"60","author":[{"given":"Anastasia","family":"Garoufi","sequence":"first","affiliation":[{"name":"Second Department of Pediatrics National and Kapodistrian University of Athens, Medical School P &amp; 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