{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:31:52Z","timestamp":1771036312374,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fever rather than diarrhea or vomiting was the most common symptom of neonatal rotavirus (<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>) infection in our previous study. We investigated whether <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> infection is a major cause of neonatal fever and compared the clinical characteristics of bacterial infection, viral infection and unknown causes of neonatal fever.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We reviewed the electronic medical records of 48 newborns aged \u226428 days who were admitted to the Special Care Nursery of Hanyang University Guri Hospital for fever (\u226538\u00b0C) from 2005 to 2009. All the newborns underwent complete blood count, urinalysis, C\u2010reactive protein, cultures of blood, urine, and cerebrospinal fluid as well as stool <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> enzyme\u2010linked immunosorbent assay. Respiratory virus polymerase chain reaction for cough or rhinorrhea, and stool culture for diarrhea were also done.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All the babies were term, with mean age 13 \u00b1 8 days and peak body temperature 38.5 \u00b1 0.5\u00b0C. The causes of neonatal fever were viral (44%), bacterial (10%) and unknown (46%). The viral infections included <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> (<jats:italic>n<\/jats:italic> = 12), enterovirus (<jats:italic>n<\/jats:italic> = 6), respiratory syncytial virus (<jats:italic>n<\/jats:italic> = 2), and rhinovirus (<jats:italic>n<\/jats:italic> = 1). All the rotavirus genotypes were G4P[6]. Only three of 12 <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\u2010infected febrile newborns had diarrhea. The bacterial infections included three cases of urinary tract infection (<jats:italic>Escherichia coli<\/jats:italic>,<jats:italic> n<\/jats:italic> = 2; <jats:italic>Klebsiella pneumoniae<\/jats:italic>,<jats:italic> n<\/jats:italic> = 1), and two cases of sepsis complicated with meningitis (all <jats:italic>Streptococcus agalactiae<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> infection is the most common single cause of neonatal fever. It may be necessary to include stool <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> tests for febrile newborns.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13504","type":"journal-article","created":{"date-parts":[[2017,12,31]],"date-time":"2017-12-31T08:06:39Z","timestamp":1514707599000},"page":"366-371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Rotavirus infection as a frequent cause of neonatal fever"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4915-3871","authenticated-orcid":false,"given":"Ha\u2010Na","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Pediatrics Hanyang University Hospital Guri Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Kyung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hanyang University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun\u2010Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hanyang University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Hwa","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hanyang University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Won","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hanyang University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Ryul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hanyang University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2000.110820"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.6.1662"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1481803500009623"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199204000-00001"},{"key":"e_1_2_8_6_1","first-page":"311","article-title":"The epidemiologic characteristics and infection control measures for an outbreak of rotavirus infection in the neonatal unit","volume":"37","author":"Jang J","year":"2005","journal-title":"Infect Chemother."},{"key":"e_1_2_8_7_1","first-page":"33","article-title":"Report of newborn deaths at post\u2010delivery care facilities in 2001 and 2002","volume":"26","author":"Yang KM","year":"2002","journal-title":"Korean J. 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