{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T05:05:04Z","timestamp":1754111104155,"version":"3.37.3"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T00:00:00Z","timestamp":1525737600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic <jats:italic>Helicobacter pylori<\/jats:italic> infection in children induces lymphoid hyperplasia called nodular gastritis (<jats:styled-content style=\"fixed-case\">NG<\/jats:styled-content>) at the antral gastric mucosa. The aim of this study was to evaluate genes in gastric biopsy on microarray analysis, to identify molecules associated with <jats:styled-content style=\"fixed-case\">NG<\/jats:styled-content> on comparison with <jats:styled-content style=\"fixed-case\">NG<\/jats:styled-content>\u2010negative pediatric corpus tissue and with <jats:italic>H. pylori<\/jats:italic>\u2010infected adult tissue with atrophic gastritis (<jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight pediatric and six adult <jats:italic>H. pylori<\/jats:italic>\u2010infected patients, as well as six pediatric and six adult uninfected patients were evaluated. All infected adults had <jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">NG<\/jats:styled-content> was observed in the antrum of all eight pediatric patients and in the corpus of three patients. Adult and uninfected patients were free of <jats:styled-content style=\"fixed-case\">NG<\/jats:styled-content>; that is, only pediatric <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic>\u2010infected patients had <jats:styled-content style=\"fixed-case\">NG<\/jats:styled-content>. Total <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> was purified from gastric biopsy, and microarray analysis was performed to compare gene expression between groups. The three infected children with <jats:styled-content style=\"fixed-case\">NG<\/jats:styled-content> in both the antrum and corpus were excluded from analysis of corpus samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of genes significantly up\u2010 or downregulated (fold change &gt;3, <jats:italic>P<\/jats:italic> &lt; 0.01) compared with uninfected controls varied widely: 72 in pediatric antrum, 45 in pediatric corpus, 103 in adult antrum and 71 in adult corpus. Nineteen genes had significantly altered expression in the antrum of <jats:styled-content style=\"fixed-case\">NG<\/jats:styled-content> tissue compared with <jats:styled-content style=\"fixed-case\">NG<\/jats:styled-content>\u2010negative pediatric corpus tissue and adult <jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content> tissue. The <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20 B\u2010cell specific differentiation antigen had the most pronounced increase. Previously described regulators of <jats:styled-content style=\"fixed-case\">NG<\/jats:styled-content> development were not predominantly upregulated in the <jats:styled-content style=\"fixed-case\">NG<\/jats:styled-content> mucosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20 overexpression may play an important role in lymphoid follicle enlargement and <jats:styled-content style=\"fixed-case\">NG<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13527","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T22:13:48Z","timestamp":1518041628000},"page":"446-454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Host response genes associated with nodular gastritis in <i>Helicobacter pylori<\/i> infection"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5493-6504","authenticated-orcid":false,"given":"Tamaki","family":"Ikuse","sequence":"first","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Juntendo University Graduate School of Medicine Tokyo Japan"},{"name":"Department of Pediatrics University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikazu","family":"Ohtsuka","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naho","family":"Obayashi","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Jimbo","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yo","family":"Aoyagi","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Asaoka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Hojo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Nagahara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumio","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J","family":"Czinn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207726"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70096-8"},{"key":"e_1_2_8_4_1","first-page":"1","article-title":"Biological agents. 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