{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T05:07:01Z","timestamp":1773896821490,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T00:00:00Z","timestamp":1527465600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25461627"],"award-info":[{"award-number":["25461627"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Urinary liver\u2010type fatty acid\u2010binding protein (uL<\/jats:styled-content>\u2010FABP<\/jats:styled-content>) has recently been identified as a biomarker for kidney injury. uL<\/jats:styled-content>\u2010FABP<\/jats:styled-content> excretion in pediatric relapsing nephrotic syndrome and tubular dysfunction, however, has not been reported previously.<\/jats:p><\/jats:sec>Methods<\/jats:title>We measured uL<\/jats:styled-content>\u2010FABP<\/jats:styled-content> level in children with steroid\u2010sensitive nephrotic syndrome (SSNS<\/jats:styled-content>), in those with tubular dysfunction, and in control subjects.<\/jats:p><\/jats:sec>Results<\/jats:title>uL<\/jats:styled-content>\u2010FABP<\/jats:styled-content> was markedly increased in relapsing SSNS<\/jats:styled-content> (median, 30.3\u00a0\u03bcg\/gC<\/jats:styled-content>r; range, 12.6\u2013171.0\u00a0\u03bcg\/gC<\/jats:styled-content>r; n<\/jats:italic>\u00a0= 13), and also in the tubular dysfunction group (median, 164.8\u00a0\u03bcg\/gC<\/jats:styled-content>r; range, 41.6\u2013834.5\u00a0\u03bcg\/gC<\/jats:styled-content>r; n<\/jats:italic> = 7), compared with the control subjects (median, 3.0\u00a0\u03bcg\/gC<\/jats:styled-content>r; range, 1.1\u201313.9\u00a0\u03bcg\/gC<\/jats:styled-content>r; n<\/jats:italic> = 21). uL<\/jats:styled-content>\u2010FABP<\/jats:styled-content> level was significantly correlated with urinary protein excretion in the SSNS<\/jats:styled-content> group, and in the total group. Additionally, in the SSNS<\/jats:styled-content> group, elevated uL<\/jats:styled-content>\u2010FABP<\/jats:styled-content> in the relapsing stage returned to a level similar to that in the control group on remission of NS<\/jats:styled-content>. In the tubular dysfunction group, uL<\/jats:styled-content>\u2010FABP<\/jats:styled-content> was significantly correlated with urinary \u03b22\u2010microglobulin.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Urinary protein amount, and the ability of the proximal tubules to reabsorb low\u2010molecular\u2010weight proteins, should also be considered when evaluating the clinical significance of uL<\/jats:styled-content>\u2010FABP<\/jats:styled-content> as a biomarker for kidney injury in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13533","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T19:04:52Z","timestamp":1519239892000},"page":"442-445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Urinary liver\u2010type fatty acid\u2010binding protein in pediatric nephrotic syndrome and tubular dysfunction"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1768-6996","authenticated-orcid":false,"given":"Masashi","family":"Nishida","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kyoto Prefectural University of Medicine Graduate School of Medical Science Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Kawakatsu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kyoto City Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Hamaoka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Uji\u2010Tokushukai Medical Center Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-7364-5-3-170"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.07.070187.002005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M011623200"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2015.03.017"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007010097"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2011.02620.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.05.020"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2011.09.018"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lab.2003.08.001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63384-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2011.01469.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft394"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80697-1"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700240"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13533","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.13533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T22:32:12Z","timestamp":1694730732000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.13533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/ped.13533"],"URL":"https:\/\/doi.org\/10.1111\/ped.13533","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"2017-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}