{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:41:10Z","timestamp":1784259670823,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Thyroid function in asphyxiated newborns who received hypothermia therapy and its relation to neurological outcome are not well described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a prospective study to measure thyroid function in 12 asphyxiated newborns who received hypothermia therapy. We measured serum thyroid\u2010stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) on admission, at 24, 72, and 96 h after birth, and at discharge (range, 17\u201354 days). The 12 newborns were divided into two groups based on the presence of brain injury on head magnetic resonance imaging (six in the abnormal imaging group and six in the normal imaging group), and thyroid function was compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum TSH was within the normal range in the 12 newborns. Serum FT3 and FT4 remained low at 24, 72, and 96 h after birth, and returned to normal range at discharge in the 12 newborns. There was no significant difference in serum TSH between the two groups, but serum FT3 at 96 h after birth, and serum FT4 at 72 and 96 h after birth, were significantly lower in the abnormal imaging group than in the normal imaging group (<jats:italic>P<\/jats:italic> = 0.02; <jats:italic>P<\/jats:italic> = 0.03; and <jats:italic>P<\/jats:italic> = 0.01, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Asphyxiated newborns have transient low thyroid hormone levels at 24\u201396 h after birth. Serum FT3 and FT4 between 72 and 96 h after birth may predict brain injury in asphyxiated newborns.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13534","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T19:04:49Z","timestamp":1519239889000},"page":"433-437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Thyroid function in asphyxiated newborns who received hypothermia therapy"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2905-3232","authenticated-orcid":false,"given":"Akira","family":"Kobayashi","sequence":"first","affiliation":[{"name":"General Center for Perinatal, Maternal and Neonatal Medicine Niigata University Medical and Dental Hospital Niigata Japan"},{"name":"Department of Neonatology Nagaoka Red Cross Hospital Nagaoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Touhei","family":"Usuda","sequence":"additional","affiliation":[{"name":"General Center for Perinatal, Maternal and Neonatal Medicine Niigata University Medical and Dental Hospital Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Neonatology Uonuma Institute of Community Medicine Niigata University Medical and Dental Hospital Minamiuonuma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Kaneko","sequence":"additional","affiliation":[{"name":"General Center for Perinatal, Maternal and Neonatal Medicine Niigata University Medical and Dental Hospital Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinuko","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Neonatology Uonuma Institute of Community Medicine Niigata University Medical and Dental Hospital Minamiuonuma Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Niigata University Graduate School of Medical and Dental Sciences Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1985.tb04571.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80132-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1995.tb13794.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2003.tb00556.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1297\/cpe.11.1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-51-2-387"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2011.06.009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198512000-00020"},{"key":"e_1_2_8_10_1","first-page":"51","article-title":"Thyroid function in healthy and sick neonates","volume":"54","author":"Chen JY","year":"1994","journal-title":"Zhonghua Yi Xue Za Zhi (Taipei)"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.1994.7.1.39"},{"key":"e_1_2_8_12_1","first-page":"1515","article-title":"The effect of asphyxia on thyroid function in newborn infants","volume":"92","author":"Takeuchi T","year":"1988","journal-title":"J. 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