{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:12:02Z","timestamp":1783181522883,"version":"3.54.6"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T00:00:00Z","timestamp":1527465600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to investigate whether presepsin level in umbilical cord blood can be used as a predictor of early onset neonatal sepsis (<jats:styled-content style=\"fixed-case\">EONS<\/jats:styled-content>) in preterm labor with premature rupture of membranes (<jats:styled-content style=\"fixed-case\">PROM<\/jats:styled-content>), allowing rational use of antibiotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All preterm infants between 24\u00a0+\u00a00 and 36\u00a0+\u00a06\u00a0weeks of gestation born to pregnant women with <jats:styled-content style=\"fixed-case\">PROM<\/jats:styled-content> were enrolled in the study. Blood samples were obtained from clamped umbilical cords after delivery of the neonate and prior to the delivery of the placenta for C\u2010reactive protein and presepsin measurement. A diagnosis or suspicion of <jats:styled-content style=\"fixed-case\">EONS<\/jats:styled-content> was based on clinical symptoms or laboratory results in the absence of positive blood culture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 288 women were included in the study and delivered at 31\u00a0+\u00a04\u00a0weeks (range, 25\u201336\u00a0+\u00a05\u00a0weeks). Microbial invasion of the amniotic cavity was identified in 62 women (81.6%) with <jats:styled-content style=\"fixed-case\">EONS<\/jats:styled-content> and in 31 (14.6%) without (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.004). The prevalence of <jats:styled-content style=\"fixed-case\">EONS<\/jats:styled-content> was 26.4% (76\/288). Median umbilical cord presepsin was significantly higher in neonates with <jats:styled-content style=\"fixed-case\">EONS<\/jats:styled-content> than in those without: 2,231\u00a0pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> (range, 1,442\u20133,988\u00a0pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>) versus 275\u00a0pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> (range, 116\u2013326\u00a0pg\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>;<jats:italic> P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.000). On logistic regression analysis the only independent predictor of <jats:styled-content style=\"fixed-case\">EONS<\/jats:styled-content> was umbilical cord blood presepsin (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 12.6; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.5\u201328.1, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Umbilical cord blood presepsin is a predictor for <jats:styled-content style=\"fixed-case\">EONS<\/jats:styled-content> in preterm infants with <jats:styled-content style=\"fixed-case\">PROM<\/jats:styled-content> and may help to reduce the unnecessary use of antibiotics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13541","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T18:52:40Z","timestamp":1519930360000},"page":"428-432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Presepsin as a predictor of early onset neonatal sepsis in the umbilical cord blood of premature infants with premature rupture of membranes"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1304-5809","authenticated-orcid":false,"given":"Wael","family":"Seliem","sequence":"first","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira M.","family":"Sultan","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology Faculty of Medicine Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B0-72-160537-0\/50008-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318223bad2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2017"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-9-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069341"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.5847\/wjem.j.1920-8642.2011.03.011"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-1755"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-011-0254-x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-012-0435-2"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc13183"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1308"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318256905c"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-012-0347-3"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2013.186"},{"key":"e_1_2_7_16_1","first-page":"1834","article-title":"Role of presepsin in the diagnosis of late\u2010onset neonatal sepsis in preterm infants","volume":"29","author":"Topcuoglu S","year":"2016","journal-title":"J. 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