{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:46:25Z","timestamp":1770813985115,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T00:00:00Z","timestamp":1529366400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Corrected QT<\/jats:styled-content> interval (QT<\/jats:styled-content>c) on electrocardiography (ECG<\/jats:styled-content>) at rest and after exercise in a short daytime recording period may be insufficient for the diagnosis and management of long QT<\/jats:styled-content> syndrome (LQTS<\/jats:styled-content>), especially for LQTS<\/jats:styled-content> type 2 and 3. Therefore, examination of QT<\/jats:styled-content>c on Holter ECG<\/jats:styled-content> is important. We designed a method of analyzing QT<\/jats:styled-content>c on Holter ECG<\/jats:styled-content> that can be performed in daily clinical practice by combining automatic and manual measurements.<\/jats:p><\/jats:sec>Methods<\/jats:title>We reviewed the charts of healthy children (n<\/jats:italic> = 210) and LQTS<\/jats:styled-content> patients (n<\/jats:italic> = 35) aged <16\u00a0years and analyzed QT<\/jats:styled-content>c at rest and after exercise, and the maximum QT<\/jats:styled-content>c on Holter ECG<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>The QT<\/jats:styled-content>c (Fridericia's correction) of most controls and LQTS<\/jats:styled-content> patients reached the maximum at night or early in the morning. QT<\/jats:styled-content>c differed according to sex and age. In the control group, QTc on ECG of all three types tended to lengthen with age. QT<\/jats:styled-content>c after exercise was slightly longer than QT<\/jats:styled-content>c at rest, and the maximum QT<\/jats:styled-content>c on Holter ECG<\/jats:styled-content> was much longer than both, reaching >450\u00a0ms in boys and 500\u00a0ms in girls. In most LQTS<\/jats:styled-content> type 1 patients, QT<\/jats:styled-content>c after exercise and that on Holter ECG<\/jats:styled-content> tended to be long. In most LQTS<\/jats:styled-content> type 2 and 3 patients, QT<\/jats:styled-content>c at rest and that after exercise was long, and that on Holter ECG<\/jats:styled-content> tended to be much longer.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The present method of analyzing QT<\/jats:styled-content>c on Holter ECG<\/jats:styled-content>, in which automatic and manual measurements are combined, is practical and may be useful for diagnosis and risk stratification of LQTS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13556","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T17:53:11Z","timestamp":1522000391000},"page":"507-512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Maximum QT<\/scp>c on Holter electrocardiography in children"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9564-6060","authenticated-orcid":false,"given":"Yoshiharu","family":"Ogawa","sequence":"first","affiliation":[{"name":"Division of Cardiology Hyogo Prefectural Kobe Children's Hospital Kobe Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshikatsu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Cardiology Hyogo Prefectural Kobe Children's Hospital Kobe Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Kido","sequence":"additional","affiliation":[{"name":"Division of Cardiology Hyogo Prefectural Kobe Children's Hospital Kobe Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht089"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.1.89"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.08.037"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573403X10666140514103612"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.6.3.378"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00426-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01401.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1920.tb18266.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-09-0979"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.07.023"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2016.06.009"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.05.014"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.05.020"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00222-2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)02339-6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.5604\/20831862.1077547"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fped.13556","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.13556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T22:37:02Z","timestamp":1694731022000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.13556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/ped.13556"],"URL":"https:\/\/doi.org\/10.1111\/ped.13556","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"2017-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}