{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:42:00Z","timestamp":1790109720951,"version":"4.0.1"},"reference-count":91,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T00:00:00Z","timestamp":1527465600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite the presence of ganglion cells in the rectum, some patients have symptoms similar to those of Hirschsprung's disease. A consensus has yet to be established regarding the terminology for these diseases. We defined this group of diseases as \u201callied disorders of Hirschsprung's disease\u201d and compiled these guidelines to facilitate accurate clinician diagnosis and provide appropriate treatment strategies for each disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>These guidelines were developed using the methodologies in the Medical Information Network Distribution System (<jats:styled-content style=\"fixed-case\">MINDS<\/jats:styled-content>). Of seven allied disorders, isolated hypoganglionosis; megacystis\u2010microcolon\u2010intestinal hypoperistalsis syndrome; and chronic idiopathic intestinal pseudo\u2010obstruction were selected as targets of clinical questions (<jats:styled-content style=\"fixed-case\">CQ<\/jats:styled-content>). In a comprehensive search of the Japanese\u2010 and English\u2010language articles in PubMed and Ichu\u2010Shi Web, 836 pieces of evidence related to the <jats:styled-content style=\"fixed-case\">CQ<\/jats:styled-content> were extracted from 288 articles; these pieces of evidence were summarized in an evidence table.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We herein outline the newly established Japanese clinical practice guidelines for allied disorders of Hirschsprung's disease. Given that the target diseases are rare and intractable, most evidence was drawn from case reports and case series. In the <jats:styled-content style=\"fixed-case\">CQ<\/jats:styled-content>, the diagnosis, medication, nutritional support, surgical therapy, and prognosis for each disease are given. We emphasize the importance of full\u2010thickness intestinal biopsy specimens for the histopathological evaluation of enteric ganglia. Considering the practicality of the guidelines, the recommendations for each <jats:styled-content style=\"fixed-case\">CQ<\/jats:styled-content> were created with protracted discussions among specialists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinical practice recommendations for allied disorders of Hirschprung's disease are given for each <jats:styled-content style=\"fixed-case\">CQ<\/jats:styled-content>, along with an assessment of the current evidence. We hope that the information will be helpful in daily practice and future studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13559","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T23:43:40Z","timestamp":1527810220000},"page":"400-410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Japanese clinical practice guidelines for allied disorders of Hirschsprung's disease, 2017"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3272-0785","authenticated-orcid":false,"given":"Mitsuru","family":"Muto","sequence":"first","affiliation":[{"name":"The guideline establishment group for allied disorders of Hirschsprung's disease Science Research, Ministry of Health Labour and Welfare Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Matsufuji","sequence":"additional","affiliation":[{"name":"The guideline 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