{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T14:30:23Z","timestamp":1746196223262,"version":"3.37.3"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T00:00:00Z","timestamp":1526428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is limited reference data for determining the appropriate dose of propofol for individual patients. Therefore, we investigated the factors affecting propofol dosage for pediatric patients undergoing sedation for computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) simulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the electronic medical records of pediatric patients who underwent <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> simulation for proton therapy following a cancer diagnosis at the National Cancer Center (Korea) between 1 May 2012 and 30 April 2016. We evaluated the following factors, which reflect comorbidities or chronic illness in pediatric oncology patients: age, tumor lesion, preterm birth, American Society of Anesthesiologists (<jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>) classification, pre\u2010sedation temperature, history of propofol use, nothing by mouth time, chemotherapy history, pre\u2010sedation laboratory findings, regular medication (opioids, anticonvulsants), and use of diuretics. A regression analysis was performed and <jats:italic>P<\/jats:italic> &lt; 0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Electronic medical records of 84 pediatric cancer patients were used in the analysis. Patients in <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content> classes 1\u20132 required approximately 43% more propofol than patients in classes 3\u20134 (exp(\u03b2), 1.43; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.21\u20131.69, <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>American Society of Anesthesiologists class 3 or 4 is an independent indicator of decreased propofol dosage for pediatric oncology patients during sedation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13562","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T18:59:29Z","timestamp":1521831569000},"page":"535-539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Factors affecting propofol dosage for sedation in pediatric oncology"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4027-4423","authenticated-orcid":false,"given":"Tak Kyu","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boram","family":"Park","sequence":"additional","affiliation":[{"name":"Biometrics Research Branch Research Institute and Hospital Goyang Gyeonggi Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Biometrics Research Branch Research Institute and Hospital Goyang Gyeonggi Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woosik","family":"Eom","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine National Cancer Center Goyang Gyeonggi Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungwoo","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine National Cancer Center Goyang Gyeonggi Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000134810.60270.E8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31818fc334"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-2011-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pec.0000101578.65509.71"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199609000-00008"},{"key":"e_1_2_7_7_1","first-page":"1751","article-title":"Safety of propofol for conscious sedation during endoscopic procedures in high\u2010risk patients: a prospective, controlled study","volume":"98","author":"Heuss LT","year":"2003","journal-title":"Am. 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