{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T23:57:59Z","timestamp":1766102279285,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T00:00:00Z","timestamp":1529366400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scientific Research Foundation of Pamukkale University","award":["2009TPF006"],"award-info":[{"award-number":["2009TPF006"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pre\u2010eclampsia (<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>) carries an increased risk for maternal and\/or fetal mortality or serious morbidity. <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> is associated with ischemia and increased oxidative stress in the placenta, which may lead to modification of plasma albumin to ischemia\u2010modified albumin (<jats:styled-content style=\"fixed-case\">IMA<\/jats:styled-content>). The aim of this study was to investigate <jats:styled-content style=\"fixed-case\">IMA<\/jats:styled-content> and hematological parameters in mothers and in premature infants in normal and in pre\u2010eclamptic pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010five pregnant women with <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> and their premature newborns were categorized as the <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> group, and 25 normotensive pregnant women and their premature newborns as the control group. Preterm infants are classified as small for gestational age (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>) or non\u2010<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> according to the Fenton preterm growth chart. Serum <jats:styled-content style=\"fixed-case\">IMA<\/jats:styled-content>, complete blood count (<jats:styled-content style=\"fixed-case\">CBC<\/jats:styled-content>), liver function tests (<jats:styled-content style=\"fixed-case\">LFT<\/jats:styled-content>), renal function tests (<jats:styled-content style=\"fixed-case\">RFT<\/jats:styled-content>), albumin, and C\u2010reactive protein were measured in the mothers immediately before birth, and in the cord blood and serum of the newborns at 6 and 24\u00a0h after birth. Clinical and demographic data were recorded for both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>While <jats:styled-content style=\"fixed-case\">IMA<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> LFT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RFT<\/jats:styled-content> were significantly increased in the <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> group compared with the control group, albumin and <jats:styled-content style=\"fixed-case\">CBC<\/jats:styled-content> were significantly lower in the <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> group. A total of 40% of <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> newborns were <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>, 30% of whom had severe <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> (birthweight &lt;3rd percentile). Cord <jats:styled-content style=\"fixed-case\">IMA<\/jats:styled-content> was significantly increased in all preterm neonates in the <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> group compared with the control group. No mothers or neonates died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum <jats:styled-content style=\"fixed-case\">IMA<\/jats:styled-content> in addition to the prevalence of <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> were significantly increased in the <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> group. Cord blood <jats:styled-content style=\"fixed-case\">IMA<\/jats:styled-content>, therefore, might be a predictive biomarker for <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content> pregnancies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ped.13563","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T18:59:55Z","timestamp":1521831595000},"page":"553-559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ischemia\u2010modified albumin in preterm infants born to mothers with pre\u2010eclampsia"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2499-4949","authenticated-orcid":false,"given":"\u00d6zmert MA","family":"\u00d6zdemir","sequence":"first","affiliation":[{"name":"Division of Neonataology Faculty of Medicine Pamukkale University Denizli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emine","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Pamukkale University Denizli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u015far","family":"Enli","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine Pamukkale University Denizli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zer","family":"\u00d6ztekin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine Pamukkale University Denizli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hacer","family":"Ergin","sequence":"additional","affiliation":[{"name":"Division of Neonataology Faculty of Medicine Pamukkale University Denizli Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90889-O"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.02.010"},{"key":"e_1_2_8_4_1","first-page":"1","article-title":"Etiopathogenesis, prediction, and prevention of preeclampsia","volume":"17","author":"Correa PJ","year":"2016","journal-title":"Hypertens. 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